69135-90-6Relevant academic research and scientific papers
Synthesis method of nicotinoyl aniline salt
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Paragraph 0033; 0034, (2017/01/17)
The invention discloses a synthesis method of nicotinoyl aniline salt. The synthesis method comprises the following steps: (1) adding nicotinic acid and aniline into a reactor according to the weight ratio of 1:(0.6-2.5), heating to 170-190DEG C, performing reflux reaction for 2-7h, heating to 190-210DEG C, and preserving heat and reacting for 0.5-1.5h; (2) transferring the liquid obtained in the step (1) to another water container and evenly stirring, cooling to 50-70DEG C, adding hydrochloric acid or sulfuric acid, and stirring for 10-50min, to obtain nicotinoyl aniline salt liquid; and (3) adding inorganic salt to the liquid obtained in the step (2), cooling to the temperature lower than 20DEG C, and performing suction filtration, to obtain rough nicotinoyl aniline salt. The synthesis method has the beneficial effects that the synthesis method is simple to operate, the reaction conditions are easily controlled, and the synthesis method is suitable for large-scale production and popularization; the purity of the synthesized nicotinoyl aniline salt is high, and the effects are excellent; and the cost is lowered, green and environment-friendly production is achieved, the environment pollution caused by organic solvents can be greatly decreased, and the treatment cost of three wastes can be lowered.
