691406-98-1Relevant academic research and scientific papers
Preparation of chiral isoxazole carbinols via catalytic asymmetric Corey-Bakshi-Shibata reduction
Rider, Kevin C.,Burkhart, David J.,Li, Chun,Mckenzie, Andrew R.,Nelson, Jared K.,Natale, Nicholas R.
experimental part, p. 97 - 107 (2010/09/04)
A diverse set of isoxazoles, with activity in three different disease categories, was reduced asymmetrically from pro-chiral ketones to chiral alcohols using the Corey-Bakshi-Shibata methodology at the α, β, and γ positions relative to the C-5-methyl of the isoxazole. The experiments described provide an easy route to hydroxylated isoxazoles that represent the common CYP-450 3A4 metabolic site.
Catalytic asymmetric synthesis of glutamate analogues
Burkhart, David J.,McKenzie, Andrew R.,Nelson, Jared K.,Myers, Katherine I.,Zhao, Xue,Magnusson, Kathy R.,Natale, Nicholas R.
, p. 1285 - 1288 (2007/10/03)
Utilizing our lateral metalation coupled with Jacobsen's catalytic asymmetric amino nitrile synthesis, we have demonstrated the ability to synthesize isoxazole-containing amino acid glutamate analogues in high yield and high enantiomeric excesses. Chiral
