1027381-62-9

Upstream product

• 74-90-8 hydrogen cyanide 
• 107-11-9 1-amino-2-propene 
• 691407-06-4 5-(2-phenyl-2-(t-butyldiphenylsilyloxy)-ethyl)-4-(2-oxo-ethyl)-3-isoxazolecarboxylic acid ethyl ester 
• 691407-00-8 (S)-5-(2-phenyl-2-(t-butyldiphenylsilyloxy)-ethyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-3-isoxazolecarboxylic acid ethyl ester 
• 691407-04-2 5-(2-phenyl-2-(t-butyldiphenylsilyloxy)-ethyl)-4-methoxycarbonylmethyl-3-isoxazolecarboxylic acid ethyl ester 
• 691407-15-5 5-(2-phenyl-2-(t-butyldiphenylsilyloxy)-ethyl)-4-(2-hydroxy-ethyl)-3-isoxazolecarboxylic acid ethyl ester 
• 691407-02-0 5-(2-phenyl-2-(t-butyldiphenylsilyloxy)-ethyl)-4-(1-keto-ethyl)-3-isoxazolecarboxylic acid ethyl ester 
• 691406-98-1 5-(2-phenyl-2-hydroxy-ethyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-3-isoxazolecarboxylic acid ethyl ester 
• 386707-48-8 3-isoxazolecarboxylic acid 5-[(2,2-hydroxyphenyl)ethyl]-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-ethyl ester 
• 646066-64-0 5-[(2,2-ketophenyl)ethyl]-4-(2,5,5-trimethyl-1,3-dioxan-2-yl) 3-isoxazolecarboxylic acid ethyl ester 

Downstream Products

• 691407-10-0 (S,S)-5-(2-phenyl-2-hydroxy-ethyl)-4-(N-allyl-2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester 
• 691407-11-1 (S,S)-5-(2-phenyl-2-hydroxy-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Catalytic asymmetric synthesis of glutamate analogues

Utilizing our lateral metalation coupled with Jacobsen's catalytic asymmetric amino nitrile synthesis, we have demonstrated the ability to synthesize isoxazole-containing amino acid glutamate analogues in high yield and high enantiomeric excesses. Chiral