691407-27-9

Upstream product

• 67-56-1 methanol 
• 138871-58-6 (S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 691407-26-8 (4S,5S)-N-tert-butoxycarbonyl-5-tert-butyldiphenylsilyloxymethyl-2-oxopyrrolidine-4-carbaldehyde 
• 691407-25-7 (4R,5S)-N-tert-butoxycarbonyl-5-tert-butyldiphenylsilyloxymethyl-4-(2-methylprop-1-enyl)pyrrolidin-2-one 

Downstream Products

• 691407-35-9 (2S,3S)-1-(O-tert-butyldiphenylsilyl)-2-N-tert-butoxycarbonylamino-3-fluoromethylpentan-1-ol 
• 691407-33-7 (2S,3S)-2-N-tert-butoxycarbonylamino-1-tert-butyldiphenylsilyloxy-3-fluoromethyl-5-hydroxypentane 
• 691407-32-6 (3S,4S)-N-tert-butoxycarbonylamino-5-tert-butyldiphenylsilyloxy-3-fluoromethylpentanoic acid 
• 691407-34-8 (3S,4S)-O-(4-tert-butoxycarbonylamino-5-tert-butyldiphenylsilyloxy-3-fluoromethylpentyl)-1H-imidazole-1-carbothioate 
• 691407-30-4 (4S,5S)-N-tert-butoxycarbonyl-5-tert-butyldiphenylsilyloxymethyl-4-fluoromethylpyrrolidin-2-one 

Relevant academic research and scientific papers

Synthesis of (2S,3S)-3′-fluoroisoleucine

The fluorinated amino acid, (2S,3S)-3′-fluoroisoleucine, 3, has been synthesised by a route involving stereoselective cuprate or photochemical addition to the compound 4, derived in turn from (2S)-pyroglutamic acid. This provides a reporter group for the hydrophobic amino acid (2S)-isoleucine for use in protein studies.