691410-01-2Relevant academic research and scientific papers
A new chemo-enzymatic route to chiral 2-hydroxy-4-phenylbutyrates by combining lactonase-mediated resolution with hydrogenation over Pd/C
Chen, Bing,Yin, Hai-Feng,Wang, Zhen-Sheng,Liu, Jia-Ying,Xu, Jian-He
, p. 2754 - 2756 (2010)
A new chemo-enzymatic route to both isomers of 2-hydroxy-4-phenylbutyric acid is reported. The key step is the lactonase-catalyzed hydrolysis of cis- and trans-2-hydroxy-4-phenyl-4-butyrolactones followed by hydrogenation over Pd/C to afford optically pure 2-hydroxy-4-phenylbutyric acid.
