13983-60-3

Upstream product

• 5817-92-5 2,4-dioxo-4-phenylbutanoic acid 
• 6213-94-1 trimethylsiloxyethene 
• 119072-55-8 tert-butylisonitrile 
• 100-52-7 benzaldehyde 
• 71-43-2 benzene 
• 196107-42-3 (R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone 
• 1383976-99-5 (1R,3R)-4,4,4-trichloro-1-phenylbutane-1,3-diol 
• 53515-22-3 3-bromo-4-oxo-4-phenylbutanoic acid 
• 583-06-2 3-benzoylacrylic acid 
• 65245-10-5 2-hydroxy-4-oxo-4-phenylbutanoic acid 
• 146912-63-2 (S)-2-hydroxy-4-oxo-4-phenylbutanoic acid 

Downstream Products

• 345212-07-9 acide hydroxy-2 phenyl-4 (methoxy-4' phenyl)-4 butanoique 
• 82132-79-4 acide hydroxy-2 phenyl-4 (methyl-4' phenyl)-4 butanoique 
• 34532-29-1 acide hydroxy-2 diphenyl-4,4 butanoique 
• 34532-30-4 hydroxy-2 phenyl-4 tetralone-1 
• 129029-61-4 2-hydroxy-4-phenylbut-3-enoic acid 
• 2051-95-8 succinylbenzene 
• 1204769-19-6 (2S)-2-hydroxy-4-phenyl-4-butyrolactone 
• 691410-01-2 C₁₀H₁₂O₄ 

Relevant academic research and scientific papers

Stereoselective synthesis of cis- or trans-2,4-disubstituted butyrolactones from Wynberg lactone

(R)-Wynberg lactone was used to prepare various asymmetric 2,4-disubstituted butyrolactones in three to four steps. Attainment of any possible stereoisomer, based upon commencement from (R)- or (S)-4- trichloromethyl-2-oxetanone, and the capacity to insta

Facile synthesis of enantiopure 4-substituted 2-hydroxy-4butyrolactones using a robust Fusarium lactonase

A facile chemo-enzymatic process has been developed for producing stereoisomers of 4substituted 2-hydroxy-4-butyrolactones with good to excellent enantioselectivity. This process involves an easy separation of the diastereoisomers by column chromatography

Lewis base catalyzed enantioselective aldol addition of acetaldehyde-derived silyl enol ether to aldehydes

Chiral phosphoramide catalyzed-enantioselective aldol addition of an acetaldehyde-derived trialkylsilyl enol ether to aromatic aldehydes provides protected aldol products in good yields with good to excellent enantioselectivities. Preliminary studies show that the aldolization intermediate (a chlorohydrin adduct) can be trapped with tert-butyl isocyanide to form an α-hydroxy lactone with good selectivity in a singlepot operation.

Stereoselective routes to chiral 2-hydroxy-4-oxo acids and substituted 2-hydroxybutyrolactones using lactate dehydrogenases

The enantioselective reduction 2,4-dioxo acids catalysed by lactate dehydrogenases provided access to 2-hydroxy-4-oxo acids of both S and R configuration. Subsequent diastereoselective chemical reduction affords 4-substituted 2-hydroxybutyrolactones.