691410-93-2

Usage

Uses

Used in Pharmaceutical Research:
3-(5-[1,2]Dithiolan-3yl-Pentanoylamino)-Propyl-Amide is used as a research compound for exploring its potential biological activity and therapeutic effects. The presence of the dithiolan-3yl ring indicates that it may interact with biological systems in unique ways, warranting further investigation into its properties and applications.
Used in Drug Development:
In the pharmaceutical industry, 3-(5-[1,2]Dithiolan-3yl-Pentanoylamino)-Propyl-Amide is utilized as a lead compound in the development of new drugs. Its molecular structure and functionality could be optimized to target specific biological pathways or processes, potentially leading to the creation of novel therapeutic agents.

Upstream product

• 1077-28-7 Thioctic acid 
• 109-76-2 Trimethylenediamine 
• 40846-94-4 thioctic acid-N-hydroxysuccinimide ester 

Relevant academic research and scientific papers

Synthesis and characterization of new and potent α-lipoic acid derivatives

α-Lipoic acid [5-[1,2]-dithiolan-3-yl-pentanoic acid (LA)] is a natural antioxidant and cofactor of several enzymes. It increases the glucose transport activity in skeletal muscles and adipocytes in a non-insulin dependent manner. Therefore, LA is widely used in Type 2 diabetic patients as an oral auxiliary drug. However, large doses of LA (0.8-1.8 gr/day po) are required due to its unfavorable pharmacokinetic parameters. In order to improve these parameters, we synthesized ester and amide LA derivates. Two of these newly synthesized compounds, 5-[1,2]-dithiolan-3-yl-pentanoic acid 3-(5-[1,2]dithiolan-3yl-pentanoylamino)-propyl]-amide (AN-7) and 5-[1,2]-dithiolan-3-yl-pentanoic acid 3-(5-[1,2]-dithiolan-3yl-pentanoyloxy)- propyl ester (AN-8) augmented the rate glucose transport in myotubes in culture in the absence or presence of insulin. Their potency was 12-fold higher than that of the parent compound; their maximal stimulatory effect was 1.5-fold higher than that of LA. When tested in vivo in streptozotocin-diabetic C57/ Black mice, AN-7 (10 mg/kg/day for 2 weeks, sc) reduced blood glucose level by 39% while a higher dose of LA (50 mg/kg/day for 2 weeks, sc) lowered it by 30%. These results indicate that AN-7 is more potent than LA in augmenting glucose transport in skeletal muscles and reducing blood glucose in diabetic animals.