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69150-28-3

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69150-28-3 Usage

General Description

7-(3-Bromo-propoxy)-chromen-2-one is a chemical compound with the molecular formula C12H9BrO3. It is a chromenone derivative containing a propoxy group and a bromine atom. Chromenones are important pharmacophores that have been widely investigated for their potential biological activities. The presence of the 3-bromo-propoxy substituent in this compound may impart specific chemical and biological properties, and it could potentially be used for medicinal or research purposes. However, further research and testing would be needed to fully understand its potential uses and effects.

Check Digit Verification of cas no

The CAS Registry Mumber 69150-28-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,1,5 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 69150-28:
(7*6)+(6*9)+(5*1)+(4*5)+(3*0)+(2*2)+(1*8)=133
133 % 10 = 3
So 69150-28-3 is a valid CAS Registry Number.

69150-28-3Downstream Products

69150-28-3Relevant articles and documents

Synthesis and complementary complex formation properties of oligonucleotides covalently linked to new stabilizing agents

Balbi,Balbi, Alessandro,Sottofattori,Sottofattori, Enzo,Grandi,Grandi, Teresa,Mazzei,Mazzei, Mauro,Abramova,Abramova, Tatyana V.,Lokhov,Lokhov, Sergej G.,Lebedev,Lebedev, Alexander V.

, p. 4009 - 4018 (1994)

Oligodeoxyribonucleotides of different lengths have been prepared and linked to new stabilizing agents related to the coumarin family. These ODNSAs (OligoDeoxyriboNucleotides with Stabilizing Agents) were tested against acridine connected oligomers of the same sequence. Melting temperature experiments demonstrated that all ODNSAs formed complexes of increased stability with complementary sequences of deoxyribo-20-mer. The order of stability of duplexes showed that the coumarins stabilize the complexes more than the acridine and the chromone derivatives.

A highly selective colorimetric and fluorescent chemosensor for Cr2+in aqueous solutions

Rull-Barrull,d'Halluin,Le Grognec,Felpin

, p. 505 - 508 (2017)

A new rhodamine-based chemosensor was synthetized through a modified copper-catalyzed [3+2]-cycloaddition of an azidocoumarin with an alkynyl-rhodamine. Its sensing properties toward various metal cations in aqueous solutions were investigated by colorimetric changes, UV–vis and fluorescence spectroscopies. The sensor exhibited a high selectivity for Cr2+over Cr3+and other divalent cations such as Cu2+, Mg2+, Zn2+, Ca2+, Cd2+, Co2+, Hg2+and Ni2+. The linear range of detection by fluorescence spectroscopy is 0.07–3.5?mM, with a detection limit of ca. 64?μM. The binding mode of Cr2+with the sensor was rationalized through experimental evidences.

Synthesis of N-substituted indole derivatives as potential antimicrobial and antileishmanial agents

Banerjee, Uttam Chand,Bharatam, Prasad V.,Kirar, Seema,Neerupudi, Kishore Babu,Singh, Inder Pal,Singh, Sushma,Tiwari, Shweta,Wani, Aabid Abdullah

, (2020/04/08)

Leishmaniasis and microbial infections are two of the major contributors to global mortality and morbidity rates. Hence, development of novel, effective and safer antileishmanial and antimicrobial agents having reduced side effects are major priority for researchers. Two series of N-substituted indole derivatives i.e. N-substituted indole based chalcones (12a-g) and N-substituted indole based hydrazide-hydrazones (18a-g, 19a-f, 21 a-g) were synthesized. The synthesized compounds were characterized by 1H NMR, 13C NMR, Mass and FT-IR spectral data. Further these derivatives were evaluated for their antimicrobial potential against Escherichia coli, Bacillus subtilis, Pseudomonas putida and Candida viswanathii, and antileishmanial potential against promastigotes of Leishmania donovani. Compounds 18b, 18d and 19d exhibited significant activity with an IC50 of 0.19 ± 0.03 μM, 0.14 ± 0.02 μM and 0.16 ± 0.06 μM against B. subtilis which was comparable to chloramphenicol (IC50 of 0.25 ± 0.03 μM). Compounds 12b and 12c exhibited an IC50 of 24.2 ± 3.5 μM and 21.5 ± 2.1 μM in the antileishmanial assay. Binding interactions of indole based hydrazide-hydrazones were studied with nitric oxide synthase in silico in order to understand the structural features responsible for activity.

Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma

Kurt, Belma Zengin,Dag, Aydan,Do?an, Berna,Durdagi, Serdar,Angeli, Andrea,Nocentini, Alessio,Supuran, Claudiu T.,Sonmez, Fatih

, p. 838 - 850 (2019/04/25)

A series of novel bis-coumarin derivatives containing triazole moiety as a linker between the alkyl chains was synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms I, II, IX and XII were evaluated. In addition, cytotoxic effects of the synthesized compounds on renal adenocarcinoma (769P), hepatocellular carcinoma (HepG2) and breast adeno carcinoma (MDA-MB-231) cell lines were examined. While the hCA I and II isoforms were inhibited in the micromolar range, the tumor-associated isoform hCA IX and XII were inhibited in the high nanomolar range. 4-methyl-7-((1-(12-((2-oxo-2H-chromen-7-yl)oxy)dodecyl)-1H-1,2,3-triazol-4-yl)methoxy)-2H-chromen-2-one (5p) showed the strongest inhibitory activity against hCA IX with the Ki of 144.6 nM and 4-methyl-7-((1-(10-((2-oxo-2H-chromen-7-yl)oxy)decyl)-1H-1,2,3-triazol-4-yl)methoxy)-2H-chromen-2-one (5n) exhibited the highest hCA XII inhibition with the Ki of 71.5 nM. In order to better understand the inhibitory profiles of studied molecules, multiscale molecular modelling approaches were applied. Low energy docking poses of studied molecules at the binding sites of targets have been predicted. In addition, electrostatic potential surfaces (ESP) for binding sites were also generated to understand interactions between proteins and active ligands.

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