Tetrahedron p. 4009 - 4018 (1994)
Update date:2022-08-11
Topics:
Balbi
Balbi, Alessandro
Sottofattori
Sottofattori, Enzo
Grandi
Grandi, Teresa
Mazzei
Mazzei, Mauro
Abramova
Abramova, Tatyana V.
Lokhov
Lokhov, Sergej G.
Lebedev
Lebedev, Alexander V.
Oligodeoxyribonucleotides of different lengths have been prepared and linked to new stabilizing agents related to the coumarin family. These ODNSAs (OligoDeoxyriboNucleotides with Stabilizing Agents) were tested against acridine connected oligomers of the same sequence. Melting temperature experiments demonstrated that all ODNSAs formed complexes of increased stability with complementary sequences of deoxyribo-20-mer. The order of stability of duplexes showed that the coumarins stabilize the complexes more than the acridine and the chromone derivatives.
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