69182-55-4

Usage

Compound type

Organic compound

Structure

Consists of a butane molecule with an amino group (-NH2) and an oxyamino group (-N-O-) attached

Functionality

Bifunctional molecule

Reactivity

Can act as both a nucleophile (electron donor) and a reactive oxygen species (ROS) scavenger

Therapeutic potential

Studied for its potential as a therapeutic agent for neurodegenerative diseases

Protective properties

Ability to protect cells from oxidative stress

Industrial applications

Investigated for its use in the synthesis of various organic compounds, including peptides and pharmaceuticals

InChI:InChI=1/C4H12N2O/c5-3-1-2-4-7-6/h1-6H2

Upstream product

• 69182-53-2 N-(4-aminooxy-butyl)-phthalimide 
• 203435-53-4 N-(4-aminobutoxy)carbamic acid tert-butyl ester 
• 110882-76-3 N-(4-phthalimidobutoxy)phthalimide 
• 69182-54-3 N-(4-Amino-butoxy)-acetimidic acid ethyl ester 

Relevant academic research and scientific papers

Design and Synthesis of an RGD Peptidomimetic-Paclitaxel Conjugate Targeting α v β 3 Integrin for Tumour-Directed Drug Delivery

A 1,2,3-triazole-based RGD peptidomimetic having nanomolar affinity for α v β 3 integrin was conjugated to the potent antimitotic paclitaxel via an oxime heterobifunctional linker. The resulting construct maintained nanomolar binding

17β-O-aminoalkyloximes of 5β-androstane-3β, 14β-diol with digitalis- like activity: Synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na+,K+-ATPase receptor

A series of digitalis-like compounds with a 17-aminoalkoxyiminoalkyl or -alkenyl substituent was synthesized and evaluated for inhibition of Na+,K+-ATPase and for inotropic activity. The highest inhibition was found with compounds having the substituent in configuration 17β and the amino group at a distance of 6 or 7 bonds from C(17) of the digitoxigenin skeleton. The presence of the oxime function strengthens the interaction with the receptor, more if α,β-unsaturated, thus mimicking the electronic situation of the unsaturated lactone in natural digitalis compounds. The most active compounds showed Na+,K+-ATPase inhibitory potencies (IC50) 17-25 times higher than the standards digitoxigenin and digoxin and 3-11 times higher inotropic potencies (EC50) in isolated guinea pig left atria. These features are supported by a molecular model suggesting the possible interactions of the groups described above with particular amino acid residues in the H1-H2 domains of Na+,K+-ATPase. Some interactions are the classical ones already described in the literature; a new, very strong interaction of the basic group with the Cys138 was found and adds new possibilities to design compounds interacting with this region of the receptor. The most interesting compounds were also studied in vivo in the anesthetized guinea pig for evaluating their inotropic effect versus the lethal dose. Compounds 9 and 12 showed a slightly higher safety ratio than digoxin and deserve further evaluation.