110882-76-3

Basic information

• Product Name: 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butoxy]-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butoxy]-1H-isoindole-1,3(2H)-dione
• CAS NO: 110882-76-3
• Molecular Formula: C20H16N2O5
• Molecular Weight: 364.35144
• Mol File: 110882-76-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butoxy]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butoxy]-1H-isoindole-1,3(2H)-dione(110882-76-3)
• EPA Substance Registry System: 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butoxy]-1H-isoindole-1,3(2H)-dione(110882-76-3)

Safety Data

• Hazardous Substances Data: 110882-76-3(Hazardous Substances Data)

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 24697-70-9 N-(4-hydroxybutyl)phthalimide 

Downstream Products

• 69182-55-4 O-(4-aminobutyl)hydroxylamine 

Relevant articles and documents

Ligand-Enabled β-Methylene C(sp3)?H Arylation of Masked Aliphatic Alcohols

Despite recent advances, reactivity and site-selectivity remain significant obstacles for the practical application of C(sp3)?H bond functionalization methods. Here, we describe a system that combines a salicylic-aldehyde-derived L,X-type directing group with an electron-deficient 2-pyridone ligand to enable the β-methylene C(sp3)?H arylation of aliphatic alcohols, which has not been possible previously. Notably, this protocol is compatible with heterocycles embedded in both alcohol substrates and aryl coupling partners. A site- and stereo-specific annulation of dihydrocholesterol and the synthesis of a key intermediate of englitazone illustrate the practicality of this method.