69182-93-0

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 109-70-6 1.3-chlorobromopropane 
• 69182-96-3 methyl [4-(3-chloropropoxy)phenyl]acetate 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 

Downstream Products

• 69182-94-1 {4-[3-(4-Chloro-phenoxy)-propoxy]-phenyl}-acetic acid 
• 117535-97-4 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide 
• 117536-02-4 3-<4-(3-ethoxypropoxy)phenyl>-4-methyl-5-benzylidenepyrrolin-2-one 
• 117536-03-5 3-<4-(N,N-diethylaminopropoxy)phenyl>-4-methyl-5-benzylidenepyrrolin-2-one 
• 117535-98-5 4-<3-(N,N-diethylamino)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide 
• 117536-06-8 3-<4-<3-(N-hydroxyethyl-N-methyl)aminopropoxy>phenyl>-4-methyl-5-benzylidenepyrrolin-2-one 
• 117536-01-3 4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide 
• 117536-04-6 3-<4-<3-(N-piperidinyl)propoxy>phenyl>-4-methyl-5-benzylidenepyrrolin-2-one 
• 117535-99-6 4-<3-(N-piperidyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide 
• 117536-05-7 3-<4-<3-(N-morpholinyl)propoxy>phenyl>-4-methyl-5-benzylidenepyrrolin-2-one 
• 117536-00-2 4-<3-(N-morpholinyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide 
• 117536-07-9 Dodecyl-diethyl-[3-(4-{4-methyl-2-oxo-5-[1-phenyl-meth-(Z)-ylidene]-2,5-dihydro-1H-pyrrol-3-yl}-phenoxy)-propyl]-ammonium; bromide 
• 185803-05-8 5-{2-[4-(3-Chloro-propoxy)-phenyl]-acetyl}-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one 

Relevant academic research and scientific papers

Novel 8-(p-substituted-phenyl/benzyl)xanthines with selectivity for the A2A adenosine receptor possess bronchospasmolytic activity

A new series of 8-(p-substituted-phenyl/benzyl)xanthines has been synthesized and evaluated in vitro for adenosine receptor binding affinity and in vivo for bronchospasmolytic effects. It was observed that the nature of substituent at para-position of 8-phenyl/benzyl group on the xanthine scaffold remarkably affects the binding affinity and selectivity of xanthine derivatives for various adenosine receptor subtypes and also their bronchospasmolytic effects. Newly synthesized 8-phenylxanthines displayed potent binding affinity and significant selectivity for A2A receptors and also produced potent bronchospasmolytic effects. Replacement of phenyl ring with benzyl moiety at C8 of xanthine skeleton resulted in notable reduction in adenosine receptor affinity and broncholytic effects.

Synthesis and biological evaluation of phenylacetyl derivatives having low central nervous system permeability as potent and selective M2 muscarinic receptor antagonists

A series of phenylacetyl derivatives containing the 5,10-dihydro-11H- dibenzo[b,e][1,4]diazepin-11-one or 5,11-dihydro-6H-pyrido[2,3- b][1,4]benzodiazepin-6-one skeleton was prepared and evaluated for their binding affinities to muscarinic receptors in vitro and for antagonism of bradycardia, salivation and tremor in vivo. Among them, compounds 56 and 66 had high affinity for M2 muscarinic receptors in the heart (pK(i) = 8.7 and 8.9, respectively) with low affinity for M3 muscarinic receptors in the submandibular gland. A structure-activity relationship (SAR) study suggested that the high M2 selectivity over the M3 muscarinic receptors of 56 may be attributed to the direction of the carboxamide carbonyl group. In in vivo studies, 56 and 66 antagonized oxotremorine-induced bradycardia in rats on both intravenous and oral administration, and their heart rate increasing effect in dogs with nocturnal bradycardia was about 3-fold greater than that of AF-DX 116. Furthermore, they had almost no influence on oxotremorine- induced tremor in mice, presenting no evidence of central transfer.

Synthesis of Amino Derivatives of 5-Aralkylidene-3-pyrrolin-2-ones

Preparation of some derivatives of 5-aralkylidene-3-pyrrolin-2-ones is reported.Compounds with an amino group on the phenyl ring at the 3-position of the pyrrolinone ring showed suitable properties as potential UV-A filters.Some of the compounds were quat