691860-37-4Relevant academic research and scientific papers
Post-synthetic functionalization of tryptophan protected peptide sequences through indole (C-2) photocatalytic alkylation
Ackermann, Lutz,Berlinck, Roberto G. S.,Bernardi, Darlon I.,Delgado, José A. C.,Kaplaneris, Nikolaos,Lima, Rafaely N.,Paix?o, Márcio W.
supporting information, p. 5758 - 5761 (2021/06/16)
We report a selective, mild, and efficient C-H functionalization of tryptophan and tryptophan-containing peptides with activated α-bromo-carbonyl compounds under visible-light irradiation. The protocol efficiency is outlined by the wide substrate scope and excellent tolerance of sensitive functional groups present in the amino acid side chains. The method can be successfully extended to access pharmaco-peptide conjugate scaffolds.
NOVEL COMPOSITIONS FOR REDUCING A? 42 PRODUCTION AND THEIR USE IN TREATING ALZHEIMER'S DISEASE (AD)
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Page/Page column 40; 41, (2011/08/08)
Novel small molecule compounds for reduction of A? 42 production and for treatment of Alzheimer's Disease and other neurodegenerative disorders, methods of making them and pharmaceutical compositions containing them are described.
Useful synthesis of aryl cinnamates: synthesis of difengpin
Mall, Raghao S.,Papalkar, Abhijit S.
, p. 1001 - 1013 (2007/10/03)
A convenient high yield and general method is described for the synthesis of difengpin (8a) and aryl cinnamates (8b-h and 9a,b) from benzaldehydes (7a-h)
