691872-18-1Relevant academic research and scientific papers
Catalytic Strategy for Regioselective Arylethylamine Synthesis
Boyington, Allyson J.,Seath, Ciaran P.,Zearfoss, Avery M.,Xu, Zihao,Jui, Nathan T.
supporting information, p. 4147 - 4153 (2019/03/07)
A mild, modular, and practical catalytic system for the synthesis of the highly privileged phenethylamine pharmacophore is reported. Using a unique combination of organic catalysts to promote the transfer of electrons and hydrogen atoms, this system performs direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol. The utility of this process is highlighted by its scalability and the modular synthesis of an array of bioactive small molecules.
Small molecular PET photographic developer of target chemokine receptor CXCR4
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Paragraph 0052-0056, (2020/01/08)
The invention relates to a small molecular PET photographic developer of a target chemokine receptor CXCR4 and a preparation method of the small molecular PET photographic developer. According to thesmall molecular PET photographic developer of the target
Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: Structure-activity relationships, lead optimization, and chronic in vivo efficacy
Phillips, Dean P.,Gao, Wenqi,Yang, Yang,Zhang, Guobao,Lerario, Isabelle K.,Lau, Thomas L.,Jiang, Jiqing,Wang, Xia,Nguyen, Deborah G.,Bhat, B. Ganesh,Trotter, Carol,Sullivan, Heather,Welzel, Gustav,Landry, Jannine,Chen, Yali,Joseph, Sean B.,Li, Chun,Gordon, W. Perry,Richmond, Wendy,Johnson, Kevin,Bretz, Angela,Bursulaya, Badry,Pan, Shifeng,McNamara, Peter,Seidel, H. Martin
, p. 3263 - 3282 (2014/05/20)
Activation of the G-protein coupled receptor (GPCR) Takeda G-protein receptor 5 (TGR5), also known as G-protein bile acid receptor 1 (GPBAR1), has been shown to play a key role in pathways associated with diabetes, metabolic syndrome, and autoimmune disease. Nipecotamide 5 was identified as an attractive starting point after a high-throughput screen (HTS) for receptor agonists. A comprehensive hit-to-lead effort culminated in the discovery of 45h as a potent, selective, and bioavailable TGR5 agonist to test in preclinical metabolic disease models. In genetically obese mice (ob/ob), 45h was as effective as a dipeptidyl peptidase-4 (DPP-4) inhibitor at reducing peak glucose levels in an acute oral glucose tolerance test (OGTT), but this effect was lost upon chronic dosing.
3-PYRIDINYLETHYLBENZAMIDE DERIVATIVES AS FUNGICIDES
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Page/Page column 24, (2008/06/13)
Compound of general formula (I). Process for preparing this compound. Intermediate of general formula (II) to prepare compound of formula (I). Intermediate of general formula (V) to prepare compound of formula (I). Fungicidal composition comprising a comp
