691876-43-4

Upstream product

• 139354-85-1 ethyl 2-(2-tert-butoxycarbonylaminothiazol-4-yl)-3-formylpropanoate 
• 771-99-3 4-phenylpiperidine 
• 86978-09-8 tert-butyl (2E)-2-[(tert-butoxycarbonyl)inimo]-4-(2-ethoxy-2-oxoethyl)-1,3-thiazole-3-(2H)-carboxylate 
• 139354-84-0 ethyl 2-(2-tert-butoxycarbonylaminothiazol-4-yl)-4-pentenoate 

Downstream Products

• 929008-08-2 {4-[1-(3,5-bis-trifluoromethyl-benzylcarbamoyl)-3-(4-phenyl-piperidin-1-yl)-propyl]-thiazol-2-yl}-carbamic acid tert-butyl ester 
• 929008-01-5 {4-[1-(3,5-bis-trifluoromethyl-benzylcarbamoyl)-3-(4-phenyl-piperidin-1-yl)-propyl]-thiazol-2-yl}-carbamic acid tert-butyl ester 
• 929008-02-6 2-(2-amino-thiazol-4-yl)-N-(3,5-bis-trifluoromethyl-benzyl)-4-(4-phenyl-piperidin-1-yl)-butyramide 
• 929008-09-3 2-(2-amino-thiazol-4-yl)-N-(3,5-bis-trifluoromethyl-benzyl)-4-(4-phenyl-piperidin-1-yl)-butyramide 
• 691876-44-5 2-(2-tert-butoxycarbonylamino-thiazol-4-yl)-4-(phenyl-4'-piperidine)butanoic acid 

Relevant academic research and scientific papers

α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

A series of racemic and homochiral α-aminothiazole-γ-aminobutyroamides that display high affinities for human and murine CCR2 and functional antagonism by inhibition of monocyte recruitment are described. A representative example is (2S)-2-[2-(acetylamino