691903-86-3

Upstream product

• 501-97-3 4-hydroxyphenylpropionic acid 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 691899-32-8 methyl 4-[[4-(benzoylamino)phenyl]methoxy]benzenepropanoate 
• 691904-02-6 methyl 3-{4-[(4-aminobenzyl)oxy]phenyl}-propanoate 

Relevant academic research and scientific papers

Discovery of the First Environment-Sensitive Fluorescent Probe for GPR120 (FFA4) Imaging

GPR120, which is activated by long-chain free fatty acids (FFAs), has been recognized as a new attractive target for the treatment of type 2 diabetes and metabolic disease. The visualization and location of GPR120 in native cells can provide powerful information for guiding the physiological and pathological studies of GPR120. We report herein the first potent fluorescent probes that sensitively detect GPR120. We designed and synthesized a series of novel environment-sensitive probes with suitable fluorescence property, high biological activity on the GPR120, and acceptable cytotoxicity. These fluorescent probes targeting GPR120 are expected to expand the toolkit for further studies on GPR120.

RECEPTOR FUNCTION CONTROLLING AGENT

The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.