69193-56-2Relevant articles and documents
Reactions of 2,3-Dibromo-2-methylpropanamides Promoted by Potassium tert-Butoxide
Galeeva, A. M.,Miftakhov, M. S.,Selezneva, N. K.,Valiullina, Z. R.
, p. 1643 - 1649 (2021/12/13)
Abstract: 2,3-Dibromo-2-methylpropanamides with different substituents on the nitrogen atom were synthe-sized, and their transformations by the action of potassium tert-butoxide in THF were studied. 2,3-Dibromo-N-(4-methoxyphenyl)-2-methylpropanamide and 2,3-dibromo-N-(2,5-dibromo-4-methoxyphenyl)-2-methyl-propan-amide reacted with 1–2 equiv of t-BuOK to give the corresponding N-substituted 3-bromo-3-methyl- and 3-methylideneazetidin-2-ones with acceptable yields and selectivity. Increase of the amount of t-BuOK to 3–5 equiv led to significant reduction of the yield of vinyl bromides and 3-methylideneazetidin-2-ones. On the other hand, the reaction of 2,3-dibromo-N-(tert-butyl)-2-methylpropanamide with t-BuOK afforded 3-(tert-bu-toxymethyl)-1-tert-butylazetidin-2-one with a good yield and selectivity.
Carbamoyl radical-mediated synthesis and semipinacol rearrangement of β-lactam diols
Betou, Marie,Male, Louise,Steed, Jonathan W.,Grainger, Richard S.
, p. 6505 - 6517 (2014/06/09)
In an approach to the biologically important 6-azabicyclo[3.2.1]octane ring system, the scope of the tandem 4-exo-trig carbamoyl radical cyclization - dithiocarbamate group transfer reaction to ring-fused β-lactams is evaluated. β-Lactams fused to five-,
New synthesis of β-lactams
Mori,Chiba,Okita,et al.
, p. 375 - 385 (2007/10/02)
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