69200-92-6Relevant academic research and scientific papers
Cobalt-catalyzed regioselective hydrohydrazination of epoxides
Liu, Xiangyu,Song, Heng,Tung, Chen-Ho,Wang, Wenguang,Zhai, Xiaofang
supporting information, p. 1572 - 1576 (2020/03/05)
Using an air-stable cobalt catalyst [Cp?Co(1,2-Ph2PC6H4S)(NCMe)]BF4 (1, Cp? = Me5C5-), we have achieved catalytic regioselective hydrohydrazination of epoxides to 1,1-hydrazinoalcohols in an atom-economical manner. The catalysis involves a cobalt-hydrazine intermediate, in which the NH2 group of the hydrazine binds to the metal center, inhibiting its nucleophilic reactivity and allowing the NH group to participate in the regioselective hydrohydrazination.
1-PHENYLAZO-1-ALKENES
Schantl, Joachim G.,Hebeisen, Paul
, p. 395 - 406 (2007/10/02)
Aliphatic aldehyde phenylhydrazones 1 were converted into 1-phenylazo-1-alkenes 3 either by the reaction with I2 and pyridine followed by base induced 1,4-elimination of pyridine.HI (Method A), or via N-(4-methylbenzenesulfonyl)-N-phenylhydrazones 7 which undergo 1,4-elimination of p-toluenesulfinic acid upon treatment with KOt-Bu (Method B).Both procedures yield mixtures of configurational isomers of the phenylazo-alkenes EE- and EZ- 3b-3e; Method B is giving rise to the kinetically controlled isomer mixture (EZ-3 predominant), which equilibrates to the thremodynamicratio (EE-3 predominant) as afforded by Method A.
