69211-49-0

Upstream product

• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 81-07-2 saccharin 

Relevant academic research and scientific papers

Benzyne-Induced Ring Opening Reactions of DABCO: Synthesis of 1,4-Disubstituted Piperazines and Piperidines

The 2-(4-phenylpiperazin-1-yl)ethan-1-amine scaffold is a structurally important motif that occurs frequently in medicinal and pharmaceutical chemistry. Despite the significance of this moiety, general strategies for its synthesis to date have required mu

2-Substituted benzisothiazol-3-ones

2-Substituted benzisothiazol-3-ones are provided having the structure STR1 wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, or nitro; R1 is hydrogen, lower alkoxy or halogen, with the proviso that R1 can be lower alkoxy or halogen only when R is lower alkoxy or halogen, respectively; X is hydrogen, halogen, lower alkyl, lower alkoxy, or trifluoromethyl; Y is C or N, where Y is C, --------represents a single or double bond, and when Y is N, --------represents a single bond, p is 0 or 2, A is an alkylene group containing 2 to 5 carbons in the normal chain; and B is a single bond or an alkylene group containing from 1 to 3 carbons in the normal chain, and physiologically acceptable acid-addition salts thereof. These compounds have antiinflammatory activity, sedative and muscle relaxant activity. Pharmaceutical compositions containing such compounds and methods for using such compounds are also provided.