69231-09-0Relevant academic research and scientific papers
A new, modular approach towards 2-(1-hydroxyalkyl)oxazolines, effective bidentate chiral ligands
Bauer, Michael,Kazmaier, Uli
, p. 2155 - 2158 (2006)
Addition of β-hydroxyisonitriles towards aldehydes gives rise to hydroxyalkyl oxazolines, an interesting class of bidentate chiral ligands. This concept allows a very easy ligand tuning and optimization of the ligand structure as illustrated in a first ex
Chiral isocyanoazides: Efficient bifunctional reagents for bioconjugation
Nenajdenko, Valentine G.,Gulevich, Anton V.,Sokolova, Nadezhda V.,Mironov, Andrey V.,Balenkova, Elizabeth S.
scheme or table, p. 1445 - 1449 (2010/05/18)
Chiral scaffolds combining isocyanide and azide groups can be effectively synthesized to permit the efficient construction of both amino (hydroxy) acids and triazole derivatives, which enables the preparation of hybrid peptide molecules by Ugi/ click or click/Ugi strategies.
Straightforward synthesis of chiral hydroxy isocyanides
Bauer, Michael,Kazmaier, Uli
experimental part, p. 2360 - 2366 (2009/09/05)
Various types of hydroxy isocyanides have been prepared from the corresponding amino alcohols. These hydroxy isocyanides are interesting building blocks for multicomponent reactions and the synthesis of (hydroxyalkyl) oxazoline ligands. The isocyanides ar
Procedure for the oxidation of β-amino alcohols to α-amino aldehydes
Sergeev, Maxim E.,Pronin, Victor B.,Voyushina, Tatiana L.
, p. 2802 - 2804 (2007/10/03)
A novel procedure for the mild oxidation of β-amino alcohols to α-amino aldehydes using commercially available manganese(IV) oxide is reported. There are several important advantages of the new method, such as high enantiopurity of the reaction and the absence of either over-oxidation or any reaction by-products during the process. A number of N-protected L-α-amino aldehydes was obtained. All new compounds were characterized by their NMR spectra and optical rotation data. Georg Thieme Verlag Stuttgart.
Ligand electronic effects in enantioselective diethylzinc additions
Casey, Mike,Smyth, Martin P.
, p. 102 - 106 (2007/10/03)
Enantiopure amino alcohols were converted into N-(2-hydroxyalkyl)formamides, which were converted into the chloro-alkylformamides. Treatment with phosphorus pentachloride and anilines, followed by basic workup, gave 2-unsubstituted imidazolines bearing va
