86937-28-2Relevant academic research and scientific papers
Procedure for the oxidation of β-amino alcohols to α-amino aldehydes
Sergeev, Maxim E.,Pronin, Victor B.,Voyushina, Tatiana L.
, p. 2802 - 2804 (2005)
A novel procedure for the mild oxidation of β-amino alcohols to α-amino aldehydes using commercially available manganese(IV) oxide is reported. There are several important advantages of the new method, such as high enantiopurity of the reaction and the absence of either over-oxidation or any reaction by-products during the process. A number of N-protected L-α-amino aldehydes was obtained. All new compounds were characterized by their NMR spectra and optical rotation data. Georg Thieme Verlag Stuttgart.
Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin
Dubowchik, Gene M.,Firestone, Raymond A.
, p. 3343 - 3346 (2007/10/03)
A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.
