69258-08-8

Upstream product

• 79-77-6 (E)-β-ionone 
• 80922-54-9 (E)-3-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-propensaeure-ethylester 
• 37384-69-3 3-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-propenoic acid 
• 14393-45-4 (E)-3-(2,6,6-trimethylcyclohex-1-enyl)acrylic acid 

Downstream Products

• 87064-25-3 (E)-4,4-dimethyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1-penten-3-one 
• 116233-33-1 methyl 4-<<2-(2,6,6-trimethylcyclohexenyl)ethylene>carboxamido>benzoate 
• 162793-04-6 methyl 5-<<3-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-propenoyl>amino>-2,4-pentadienoate 
• 116233-32-0 4-<<2-(2,6,6-trimethylcyclohexenyl)ethylene>carboxamido>benzoic acid 
• 947590-74-1 1-(2,6,6-trimethylcyclohex-2-en-1-yl)-7-(2,6,6-trimethylcyclohex-1-en-1-yl)-1(E),6(E)-heptadiene-3,5-dione 
• 947590-73-0 1,7-bis-(2,6,6-trimethylcyclohex-1-en-1-yl)-1(E),6(E)-heptadiene-3,5-dione 
• 100251-74-9 (E)-3-(2,6,6-trimethylcyclohex-1-en-1-yl)acrylamide 
• 52209-30-0 (E)-N,N-dimethyl-3-(2,6,6-trimethylcyclohex-1-en-1-yl)acrylamide 
• 1259012-84-4 (E)-N-methyl-3-(2,6,6-trimethylcyclohex-1-en-1-yl)acrylamide 

Relevant academic research and scientific papers

Synthesis of short retinoidal amides related to fenretinide: antioxidant activities and differentiation-inducing ability

Purpose: By a scaffold shortening strategy, a small series of retinoidal amides fenretinide (4-HPR) analogs have been synthesized from α, β-ionones and tested for their antiproliferative and differentiating activities, and antioxidant effect. Methods: The

Photocatalytic e → Z Isomerization of β-Ionyl Derivatives

An operationally simple E → Z isomerization of activated dienes, based on the β-ionyl motif intrinsic to retinal, is reported using inexpensive (-)-riboflavin (vitamin B2) under irradiation at 402 nm. Selective energy transfer from photoexcited (-)-riboflavin to the starting E-isomer enables geometrical isomerization. Since the analogous process with the Z-isomer is inefficient, microscopic reversibility is circumvented, thereby enabling a directional isomerization to generate the contra-thermodynamic product (up to 99% yield, up to 99:1 Z/E). Prudent choice of photocatalyst enables chemoselective isomerization to be achieved in both inter- and intramolecular systems. The principles established from this study, together with a molecular editing approach, have facilitated the development of a regioselective isomerization of a truncated triene based on the retinal scaffold.

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.

ANTINEOPLASTIC AND CURCUMIN DERIVATIVES AND METHODS OF PREPARATION AND USE

This invention comprises antineoplastic curcumin derivatives and methods of preparation and use thereof. Note is made of the acylation product of the lithium enolate of β-ionone using the acid chloride, 2(E)-3-(2,6,6-trimethycyclohex-1-en-1-yl)propenoyl chloride derived from β-cyclocitral. Particular reference is made to the isomeric compound, 1-(2,6,6-trimethylcyclohex-2-en-1-yl)-7-(2,6,6-trimethylcyclohex-1-en-1-yl)- 1,6-heptadiene-3,5-dione.