37384-69-3Relevant articles and documents
Synthesis and anti-metastatic effects of novel chiral ionone alkaloid derivatives
Fang, Hai-Jun,Shou, Xiao-Ai,Liu, Qian,Gan, Chun-Chun,Duan, Hong-Quan,Qin, Nan
, p. 245 - 253 (2015)
Abstract Novel chiral ionone alkaloid derivatives were synthesized and evaluated their anti-metastatic effects in human MDA-MB-231 breast cancer cells. The chiral center C-6 of derivatives exerted an important role in response to the anti-metastatic activ
OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE
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Page/Page column 148-149, (2010/12/31)
Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
Photochemical Reactions. 148th Communication. Photochemistry of Acylsilanes: Preparation, Photolyses, and Thermolyses of α,β-Unsaturated Silyl Ketones
Scheller, Markus E.,Iwasaki, Genji,Frei, Bruno
, p. 1378 - 1394 (2007/10/02)
The syntheses, photolyses, and thermolyses of the α,β-unsaturated silyl ketones (E/Z)-7, (E)-8, and (E)-9 are described.On n,?*-excitation (λ > 347 mm), the aforementioned compounds undergo (E/Z)-isomerization followed by γ-H abstraction.The intermediate enols are trapped intermolecularly by siloxycarbenes leading to the dimeric acetals 27A + B, 30A + B, and 31A + B.In addition, the acylsilanes (E/Z)-7 undergo photoisomerization by δ-H abstraction furnishing the acylsilanes 29A + B.Flash vacuum thermolyses (FVT) of (E/Z)-7, (E/Z)-8, and (E)-9 give rise to intramolecular reactions of the siloxycarbene intermediates.Thus, FVT (520 deg) of (E)- and (Z)-7 selectively leads to the enol silyl ethers 32 and (E)-33, respectively, arising from carbene insertion into an allylic C-H bond.FVT of (E/Z)-8 (560 deg) and (E)-9 (600 deg) affords the trienol silyl ethers 34A + B and the cyclic silyl ethers 37A + B, respectively, which are formed by CH insertion of the siloxycarbenes.As further products of (E)-8 and (E)-9, the bicyclic enol ethers 35 and 36 are formed, presumably via siloxycarbene addition to the cyclohexene C=C bond.
