69261-50-3

Upstream product

• 621-84-1 O-benzyl carbamate 
• 75-36-5 acetyl chloride 
• 1142-20-7 N-Cbz-Ala 
• 4132-86-9 N-benzyloxycarbonylalanine 
• 108-24-7 acetic anhydride 

Downstream Products

• 122313-52-4 benzyl N-(1-methoxyethyl)carbamate 
• 80662-87-9 3-(((benzyloxy)carbonyl)amino)propyl acetate 

Relevant academic research and scientific papers

Oxidative photo-decarboxylation in the presence of mesoporous silicas

FSM-16, a mesoporous silica, was found to catalyze oxidative photo-decarboxylation of α-hydroxy carboxylic acid, phenyl acetic acid derivatives and N-acyl-protected α-amino acids to afford the corresponding carbonyl compounds. Furthermore, FSM-16 proved to be re-usable by re-calcination at 450°C after the reaction.

Benzyl Acetylcarbamate Potassium Salt (BENAC-K): A Simple Nucleophilic N -Acetamide Equivalent

Benzyl acetylcarbamate potassium salt (BENAC-K) has been developed as a simple nucleophilic acetamide equivalent. A broad variety of alkyl halides were converted into benzyloxycarbonyl-protected N -alkylacetamides in high yields by simple treatment with an almost equimolar (1.1 equiv) amount of BENAC-K in a polar solvent.

SALT OF ISOLATED COMPOUND CONTAINING AMIDE GROUP, METHOD FOR PRODUCING THE SAME, AND METHOD FOR SYNTHESIZING AMIDE COMPOUND USING THE SAME

PROBLEM TO BE SOLVED: To provide a salt of an isolated compound containing an amide group, a method for producing the same, and a method for synthesizing an amide compound using the same. SOLUTION: The present invention provides a salt of an isolated compound containing an amide group represented by formula (1) (M is an element belonging to group 1 in the periodic table; P is a first protective group of an amine represented by R1-O(C=O)-; Q is a second protective group of an amine represented by R2-(C=O)-; R1 and R2 independently represent a substituted/unsubstituted hydrocarbon group). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Total Synthesis of Brevisamide Using an Oxiranyl Anion Strategy

A total synthesis of brevisamide, a marine monocyclic ether amide isolated from the dinoflagellate Karenia brevis, has been achieved in 18 steps starting from 4-(benzyloxy)butanol. The synthesis involves oxiranyl anion coupling between an epoxy sulfone and a triflate, intramolecular etherification of a hydroxy-bromoketone, diastereoselective introduction of the axial methyl group by hydroxyl-directed hydrogenation of an exocyclic olefin, and installation of an acetamide side chain by nucleophilic substitution of an N-acetyl carbamate. The dienal side chain is assembled using a Horner-Wadsworth-Emmons reaction to complete the synthesis.

Short communication: Silica sulfuric acid: A versatile and reusable heterogeneous catalyst for the synthesis of N-ACYL carbamates and oxazolidinones under solvent-free conditions

Silica sulfuric acid catalyzes efficiently the reaction of carbamates and oxazolidinones with anhydrides under solvent-free conditions. All the reactions were done at room temperature and the N-acyl carbamates and oxazolidinones were obtained with high yi

Synthesis of N-Acyl carbamates and oxazolidinones using HClO 4-SiO2 as catalyst under solvent-free conditions

Silica supported perchloric acid catalyzes efficiently the reaction of carbamates and oxazolidinones with anhydrides in the presence of silica sulfuric acid under solvent-free conditions. All the reactions were done at room temperature and the N-acyl carb

Method of producing an amide

The present invention discloses a new method for synthesizing an amide based on a fundamental mechanistic revision of the reaction of thio acids and organic azides. Moreover, the application of this method to the selective preparation of several classes of complex amides in nonpolar and polar solvents, including water, is provided.

New Synthetic Method of Imides through Oxidative Photodecarboxylation Reaction of N-Protected α-Amino Acids with FSM-16

FSM-16, a mesoporous silica, was found to promote the oxidative photodearboxylation of N-acyl-protected α-amino acids in hexane to afford the corresponding imides.