692729-88-7Relevant academic research and scientific papers
BROMODOMAIN INHIBITORS
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Paragraph 1542; 1543, (2015/04/28)
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.
Improved and practical procedures for the preparation of highly substituted pyridines and pyridazines via silica-mediated aromatisation
Catozzi, Nicola,Bromley, William J.,Wasnaire, Pierre,Gibson, Mairi,Taylor, Richard J. K.
, p. 2217 - 2221 (2008/02/10)
A new and straightforward procedure is described for the preparation of highly substituted pyridines and pyridazines. The method involves a Diels-Alder/retro-Diels-Alder sequence leading to dihydropyridine or related intermediates, which can be aromatized
Highly substituted pyridines via tethered imine-enamine (TIE) methodology
Raw, Steven A.,Taylor, Richard J. K.
, p. 508 - 509 (2007/10/03)
A tethered imine-enamine methodology has been developed for the direct conversion of 1,2,4-triazines into highly substituted pyridines via the inverse electron demand Diels-Alder reaction which avoids the need for a discrete aromatisation step. This TIE methodology has also been applied in one pot reaction cascades involving 1,2,4-triazines and utilising MnO 2-mediated tandem oxidation processes (TOPs).
