69274-39-1Relevant academic research and scientific papers
Regiospecific synthesis of α-diones, α,α-dialkoxyketones and α-alkoxy-α-sulfenylated ketones
Tehrani,Boeykens,Tyvorskii,Kulinkovich,De Kimpe
, p. 6541 - 6548 (2007/10/03)
A convenient synthesis of α-diones and their monoprotected acetals, i.e. α-ketoacetals, was developed by mercury induced solvolysis of regiospecifically formed α-chloro-α-(alkylthio)ketones. Analogously, α-alkoxy-α-sulfenylated ketones were formed when reacting α-chloro-α-sulfenylated ketones with an alkaline alcoholic medium, α-Alkoxy-α-sulfenylated ketones themselves could be transformed into α-diones or ?-ketoacetals, which in turn were hydrolyzed under anhydrous conditions into the corresponding α-diones. (C) 2000 Elsevier Science Ltd.
Direct deprotonation of aliphatic sulfides
Liu, Yunqi,Glass, Richard S.
, p. 8615 - 8618 (2007/10/03)
Alkylmethyl sulfides are regioselectively deprotonated by n-butyllithium and potassium tert-butoxide at the methyl group in good yields. Thiolane and thiane are deprotonated under the same conditions at the α-position in good yield.
