692765-80-3

Upstream product

• 852835-48-4 C₉H₁₁BrN₂O₄S 
• 692765-78-9 methyl N-(3-bromophenyl)-N-{[(tert-butoxycarbonyl)amino]sulfonyl}glycinate 
• 591-19-5 m-Bromoaniline 
• 126689-75-6 methyl (3-bromophenyl)glycinate 

Downstream Products

• 692764-88-8 5-(3-(1-benzofuran-2-yl)phenyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide 

Relevant academic research and scientific papers

Structure-based design of protein tyrosine phosphatase-1B inhibitors

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.

5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B

The invention concerns compounds of the formula (I) or pharmaceutically acceptable salts thereof (A chemical formula should be inserted here - please see paper copy enclosed herewith) wherein R1, R2, R3, R4, R5, and R6 have any of the meanings defined in the description. Processes for the manufacture of compounds of formula (I), compositions containing them, their use as inhibitors of protein tyrosine phosphatase PTP1B and their use for the treatment of diabetes mellitus are also described.