69299-50-9Relevant academic research and scientific papers
Efficient symmetrical bidentate dioxime ligand-accelerated homogeneous palladium-catalyzed Suzuki-Miyaura coupling reactions of aryl chlorides
Song, Jinyi,Zhao, Hongyan,Liu, Yang,Han, Huatao,Li, Zhuofei,Chu, Wenyi,Sun, Zhizhong
, p. 372 - 376 (2016/12/30)
A series of N,O-bidentate ligands were synthesized using the Vilsmeier-Haack reaction and oximation. 2,5-Dihydroxyterephthalaldehyde dioxime (L8) as an efficient N,O-symmetrical bidentate ligand was prepared from hydroquinone. It was studied as a high activity ligand for palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of aryl chlorides with arylboronic acids under mild conditions. The coupling reactions were performed in the presence of PdCl2 as the catalyst, L8 as the ligand, Na2CO3 as the base, PEG-400 as the PTC and in ethanol/water (1?:?1) as an environmentally benign solvent at 85 °C. Plentiful biaryls were obtained by the optimized reaction with good yields at a low palladium loading of 0.20 mol%.
Reactions of octahydroacridine-4-carbonitrile (carboxamide) with electrophilic reagents
Zaliznaya, Ekaterina V.,Farat, Oleg K.,Gorobets, Nikolay Yu.,Markov, Viktor I.,Zubatyuk, Roman I.,Mazepa, Aleksandr V.,Vashchenko, Elena V.
, p. 327 - 333 (2016/01/12)
[MediaObject not available: see fulltext.]Octahydroacridine-4-carbonitrile (carboxamide) was shown to react with aryldiazonium salts and other electrophilic reagents in acidic and neutral media. The reactions occurred at the methine carbon atom, forming the corresponding 4-functionalized derivatives. The obtained azo compounds decomposed at 140-155°C with elimination of nitrogen and gave products formed by the reactions of radical intermediates.
