693-92-5

Basic information

• Product Name: 3-METHYLISOTHIAZOLE
• Synonyms: 3-METHYLISOTHIAZOLE;3-methyl-1,2-thiazole;2,3-DiMethyl-isothiazoliuM
• CAS NO: 693-92-5
• Molecular Formula: C₄H₅NS
• Molecular Weight: 99.15
• Mol File: 693-92-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 167-168℃ (water )
• Boiling Point: 134℃
• Flash Point: -15.8±13.0℃
• Appearance: /
• Density: 1.121±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 309mmHg at 25°C
• Refractive Index: 1.5180 (589.3 nm 21℃)
• PKA: 4.67±0.12(Predicted)
• CAS DataBase Reference: 3-METHYLISOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLISOTHIAZOLE(693-92-5)
• EPA Substance Registry System: 3-METHYLISOTHIAZOLE(693-92-5)

Safety Data

• Hazardous Substances Data: 693-92-5(Hazardous Substances Data)

Usage

General Description

3-Methylisothiazole, also known as 3-methyl-1,2-thiazole, is a chemical compound with the molecular formula C4H5NS. It is a heterocyclic compound containing a five-membered ring with a nitrogen and sulfur atom. 3-Methylisothiazole has a sharp, acrid odor and is commonly used as a flavoring agent in the food industry, as well as a corrosion inhibitor in the oil and gas industry. It is also used as a biocide, and as a fragrance ingredient in personal care products. The compound has been found to have antimicrobial properties and is often used as a preservative in various products to extend their shelf life. However, it can also be a skin and eye irritant, and proper safety precautions should be taken when handling it.

InChI:InChI=1/C4H5NS/c1-4-2-3-6-5-4/h2-3H,1H3

Upstream product

• 693-95-8 4-Methylthiazole 
• 1423-60-5 methyl ethynyl ketone 
• 24340-76-9 3-methyl-5-aminothiazole 
• 66975-83-5 3-methyl-5-isothiazolecarboxylic acid 
• 71134-43-5 3-methyl-5-aminoisothiazole hydrochloride 

Downstream Products

• 3119-61-7 2-Benzyl-3-methyl-isothiazolium 
• 17265-43-9 (4-chloro-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 17265-44-0 (3-methyl-isothiazol-5-yl)-phenyl-methanol 
• 2939-03-9 2-<2-Nitro-benzyl>-3-methyl-isothiazolium 
• 2939-04-0 2-<3-Nitro-benzyl>-3-methyl-isothiazolium 
• 3219-92-9 2-<4-Nitro-benzyl>-3-methyl-isothiazolium 
• 930-42-7 4-bromo-3-methylisothiazole 
• 4576-90-3 3-isothiazolecarboxylic acid 
• 10271-91-7 isothiazol-3-yl-acetic acid 
• 90672-16-5 (4-Benzyloxy-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 90672-24-5 (3,4-Dimethyl-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 90672-08-5 (4-tert-Butyl-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 90672-04-1 (2-Isopropyl-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 90672-07-4 (4-sec-Butyl-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 

Relevant articles and documents

CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

Synthesis and biological evaluation of novel 1β-methylcarbapenems with isothiazoloethenyl side chains

The synthesis of novel 1β-methylcarbapenems 1a,b bearing isothiazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. Especially, 5-isothiazole derivative 1a exhibited excellent DHP-I stability and advanced pharmacokinetics profiles, compared to 5-isoxazole derivative 2, imipenem, and meropenem.