6931-84-6

Basic information

• Product Name: 1-palmitoyl-2-linoleoylphosphatidylcholine
• Synonyms: 1-palmitoyl-2-linoleoylphosphatidylcholine;1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
• CAS NO: 6931-84-6
• Molecular Formula: C₄₂H₈₀NO₈P
• Molecular Weight: 758.07
• EINECS: 232-307-2
• Mol File: 6931-84-6.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-palmitoyl-2-linoleoylphosphatidylcholine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-palmitoyl-2-linoleoylphosphatidylcholine(6931-84-6)
• EPA Substance Registry System: 1-palmitoyl-2-linoleoylphosphatidylcholine(6931-84-6)

Safety Data

• Hazardous Substances Data: 6931-84-6(Hazardous Substances Data)

Usage

Definition

ChEBI: A phosphatidylcholine 34:2 in which the 1- and 2-acyl groups are specified as hexadecanoyl (palmitoyl) and 9Z,12Z-octadecadienoyl (linoleoyl) respectively.

InChI:InChI=1/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-

Upstream product

• 60-33-3 linoleic acid 
• 17364-18-0 1-palmitoyllysophosphatidylcholine 
• 506-32-1 all cis 5,8,11,14-eicosatetraenoic acid 
• 17364-16-8 1-palmitoyl-sn-glycero-3-phosphocholine 
• 256494-19-6 1-O-palmitoyl-2-arachidonoyl-3-[methyl α-(2,4-dinitrophenyl)acetate]glycerol 
• 256494-15-2 1-O-palmitoyl-2-arachidonoyl-3-benzylglycerol 
• 256494-17-4 1-O-palmitoyl-3-[methyl α-(2,4-dinitrophenyl)acetate]glycerol 
• 1487-50-9 1-O-hexadecanoyl-3-O-benzyl-sn-glycerol 
• 57-10-3 1-hexadecylcarboxylic acid 
• 1455-05-6 2-chloroethyl phosphorodichloridate 
• 65886-78-4 1-O-palmitoyl-2-arachidonoyl-glycerol 
• 75-50-3 trimethylamine 
• 14912-92-6 caesium palmitate 
• 34688-34-1 glycerolcholine phosphate 

Downstream Products

• 54672-38-7 (R)-1,2-diacetoxy glycerylphosphoryl choline 
• 117205-52-4 1-hexadecanoyl-2-(9-carboxynonanoyl)glycerophosphocholine 
• 17364-16-8 1-palmitoyl-sn-glycero-3-phosphocholine 
• 10219-69-9 (R,S)-coriolic acid 
• 73543-67-6 (10E,12Z)-9-hydroxy-10,12-octadecadienoic acid 
• 115185-06-3 9-Hode 
• 32819-31-1 [14C]-13-Hydroxyoctadecadienoic acid 

Relevant articles and documents

Synthesis of phosphatidylcholine with conjugated linoleic acid and studies on its cytotoxic activity

Phospholipids with conjugated linoleic acid (CLA), which are potential lipid prodrugs, were synthesised. CLA was obtained by the alkali-isomerisation of linoleic acid and was subsequently used in the synthesis of 1,2-di(conjugated)linoleoyl-sn-glycero-3-phosphocholine in good (82%) yield. 1-Palmitoyl-2-(conjugated)linoleoyl-sn-glycero-3-phosphocholine was obtained by a two-step synthesis in 87% yield. All the compounds were tested in an in vitro cytotoxicity assay against two human cancer cell lines, HL-60 and MCF-7, and a mouse fibroblast cell line, Balb/3T3. The free form of CLA exhibited the highest activity against all cancer cell lines. Results obtained for the Balb/3T3 line proved that phosphatidylcholine derivatives decreased the cytotoxic effect of CLA against healthy cell lines.

Total synthesis of 2-(5,6-epoxyisoprostane A2)phosphorylcholine and elucidation of the relative configuration of the isoprostane moiety

(Chemical Equation Presented) The two possible diastereomers of 5,6-epoxyisoprostane A2 were synthesized efficiently through aldol condensations of a substituted cyclopentenone and the corresponding epoxyaldehydes (see picture). The relative configurations of the products were assigned by comparing their 1H NMR spectra with literature data. Condensation of the epoxyisoprostane A2 with lysophosphorylcholine (lyso-PC) then furnished the title lipid.

Novel pharmaceutical composition of ceftiofur

The present invention relates to a pharmaceutical oily suspension comprising cephalosporin antibiotic or its pharmaceutically acceptable salt, at least a biocompatible oil, a wetting agent, a dispersing agent and a resuspendibility enhancer, said suspension has improved properties, such as resuspendibility and chemical stability and process thereof.