693223-03-9

Upstream product

• 90362-54-2 1-[2',3',5'-tris-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl]cytosine 
• 625095-56-9 (S)-(-)-(3-chlorophenyl)-3-hydroxypropionic acid 
• 625095-57-0 (S)-(-)-1-(3-Chlorophenyl)-1,3-propanediol 
• 147-94-4 arabinosyl cytosine 
• 587-04-2 m-Chlorobenzaldehyde 
• 51699-40-2 3-(3-chlorophenyl)-3-hydroxypropionic acid ethyl ester 
• 51699-45-7 (S)-(-)-1-(3'-Chlorophenyl)-1,3-Propanediol 
• 928781-07-1 4-amino-1-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[4-(3-chloro-phenyl)-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yloxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one 
• 804561-62-4 2',3'-di-O-tert-butyldimethylsilyl-5'-O-cis-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphoshorinan-2-yl]cytosine-1-β-D-arabinofuranoside 
• 99-02-5 3'-Chloroacetophenone 
• 87418-91-5 1-[2',3'-di-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl]cytosine 
• 13422-80-5 3-(3-chlorophenyl)-3-oxopropanoic acid 

Relevant academic research and scientific papers

Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-β-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma

Cytotoxic nucleosides have proven to be ineffective for the treatment of hepatocellular carcinoma (HCC) due, in part, to their inadequate conversion to their active nucleoside triphosphates (NTP) in the liver tumor and high conversion in other tissues. Th

Design, Synthesis, and Characterization of a Series of Cytochrome P 450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver

A new class of phosphate and phosphonate prodrugs, called HepDirect prodrugs, is described that combines properties of rapid liver cleavage with high plasma and tissue stability to achieve increased drug levels in the liver. The prodrugs are substituted c