693245-44-2Relevant academic research and scientific papers
Convenient synthesis of (+)-valiolamine and (-)-1-epi-valiolamine from (-)-vibo-quercitol
Ogawa, Seiichiro,Ohishi, Yo,Asada, Miwako,Tomoda, Akihiro,Takahashi, Atsushi,Ooki, Yoriko,Mori, Midori,Itoh, Masayoshi,Korenaga, Takashi
, p. 884 - 889 (2007/10/03)
The synthesis of (+)-valiolamine and (-)-1-epi-valiolamine using bioconversion of (-)-vibo-quercitol was investigated. The quercitols were separated and purified by combination of chromatography on ion-exchange-resin columns and recrystallization. Valiolamine was isolated from fermentation broth of antibiotic validamycins. The obtained crude ketone was subjected to C-C bond formation conditions in which diazomethane was considered adequate in polar and protic solvsnts.
