693260-23-0Relevant academic research and scientific papers
99mTc-EC-guanine: Synthesis, biodistribution, and tumor imaging in animals
Yang, David J.,Ozaki, Kaoru,Oh, Chang-Sok,Azhdarinia, Ali,Yang, Thomas,Ito, Megumi,Greenwell, Allison,Bryant, Jerry,Kohanim, Saady,Wong, Vincenzo K.,Kim, E. Edmund
, p. 1471 - 1479 (2005)
Purpose. DNA markers are useful in assessing cell proliferation. The purpose of this study was to synthesize 99mTc-ethylenedicysteine- guanine (EC-Guan) for evaluation of cell proliferation. Methods. Tumor cells were incubated with 99m/su
METAL RADIOLABELED PET IMAGING AGENTS
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Page/Page column 14, (2008/06/13)
The invention relates to radiolabeled PET agents including a radioisotope, a chelator and a specific ligand. The radioisotope may include 60Cu, 62Cu, 61Cu, 64Cu and 68Ga. Generator-produced 68Ga radioisotopes may be used. Specific chelators include N2S2 moieties and N3S moieties. Specific ligands may include purine and pyrimidine bases, particularly adenine and guanine, a sugar-containing base, particularly glucosamine, galactosamine, or mannosamine, or a nitroimidazole analogue, such as a 2-nitroimidazole or a 5-nitroimidazole, particularly metronidazole. Radiolabeled agents may be formed by first forming a chelator-ligand complex, which may be stored until it is needed, at which time the radioisotope may be added. Radiolabeled agents may be used in traditional PET imaging or in dynamic PET imaging.
N2S2 chelate-targeting ligand conjugates
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Page/Page column 15-16, (2010/02/12)
The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor ang
Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
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Sheet 20, (2010/02/08)
The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor ang
