69332-47-4Relevant articles and documents
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors
Gupta, Kushol,Kaub, Carl J.,Carey, Kristen N.,Casillas, Eduard G.,Selinsky, Barry S.,Loll, Patrick J.
, p. 667 - 671 (2004)
The nonsteroidal anti-inflammatory drugs flurbiprofen and ibuprofen were modified in an attempt to alter the kinetics of inhibitor binding by COX-1. Contrary to prior predictions, a halogen substituent is not sufficient to confer slow tight-binding behavior. Conversion of the carboxylate moiety of flurbiprofen to an ester or amide abolishes slow tight-binding behavior, regardless of halogenation state.
