69358-68-5

Upstream product

• 696-63-9 4-Methoxybenzenethiol 
• 870-63-3 prenyl bromide 
• 556-82-1 3-methyl-2-buten-1-ol 
• 88927-34-8 methyl (3-methylbut-2-en-1-yl) carbonate 
• 201230-82-2 carbon monoxide 
• 78-79-5 isoprene 

Downstream Products

• 1391759-14-0 2-((4-methoxyphenyl)thio)-3,3-dimethylpent-4-enoate 
• 212687-62-2 2-(4-methoxyphenylsulfanyl)-phenylacetic acid ethyl ester 
• 1150634-45-9 ethyl 2-phenyl-2-(4-methoxyphenylthio)-3,3-dimethyl-4-pentenoate 

Relevant academic research and scientific papers

Pd/BIPHEPHOS is an Efficient Catalyst for the Pd-Catalyzed S-Allylation of Thiols with High n-Selectivity

The Pd-catalyzed S-allylation of thiols with stable allylcarbonate and allylacetate reagents offers several advantages over established reactions for the formation of thioethers. We could demonstrate that Pd/BIPHEPHOS is a catalyst system which allows the transition metal-catalyzed S-allylation of thiols with excellent n-regioselectivity. Mechanistic studies showed that this reaction is reversible under the applied reaction conditions. The excellent functional group tolerance of this transformation was demonstrated with a broad variety of thiol nucleophiles (18 examples) and allyl substrates (9 examples), and could even be applied for the late-stage diversification of cephalosporins, which might find application in the synthesis of new antibiotics. (Figure presented.).

Catalytic activation of diazo compounds using electron-rich, defined iron complexes for carbene-transfer reactions

Carbene transfer: The electron-rich iron complex Bu4N[Fe(CO) 3(NO)] efficiently catalyzes different carbene-transfer reactions. Various diazo compounds can be used. The high stability of the employed iron complexes is demonstrated by the generation of the diazo reagent in situ and a sequential iron-catalyzed allylic sulfenylation/Doyle-Kirmse reaction. Copyright

Palladium-catalyzed insertion reactions of trimethylsilyldiazomethane

Palladium(II) salts catalyze the Kirmse reaction of allylsulfides with trimethylsilyldiazomethane (TMSD) to give homoallylsulfides. Similarly, TMSD can intercept ArPdX intermediates generated during Stille couplings to give benzhydryl derivatives. The yie

Highly regioselective thiocarbonylation of conjugated dienes via palladium-catalyzed three-component coupling reactions

Three-component coupling reaction of conjugated dienes, thiols, and carbon monoxide affords an atom-economical thiocarbonylation of the dienes to give β,γ-unsaturated thioesters as the sole products. A catalyst system based on [Pd(OAc)2] and Ph