6936-36-3

Usage

Uses

Used in Pharmaceutical Research:
(Z)-3-(anilinocarbamoyl)prop-2-enoic acid is used as a chemical intermediate for the development of new drugs, given its unique structure and functional groups that can be further modified or reacted to create pharmaceutically active compounds.
Used in Organic Synthesis:
In the field of organic synthesis, (Z)-3-(anilinocarbamoyl)prop-2-enoic acid is used as a building block for synthesizing a variety of chemical compounds. Its versatile structure allows for the creation of new molecules with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Used in Drug Development:
(Z)-3-(anilinocarbamoyl)prop-2-enoic acid is used as a key component in the design and synthesis of new drug candidates. Its presence in a molecule can potentially influence the drug's pharmacological properties, such as potency, selectivity, and bioavailability, making it a valuable asset in the drug development process.
Used in Chemical Compound Synthesis:
(Z)-3-(anilinocarbamoyl)prop-2-enoic acid is used as a starting material for the synthesis of other chemical compounds, particularly those with potential applications in various industries. Its unique structure and functional groups make it an attractive candidate for further chemical modifications and reactions, leading to the creation of novel molecules with diverse properties and uses.

InChI:InChI=1/C10H10N2O3/c13-9(6-7-10(14)15)12-11-8-4-2-1-3-5-8/h1-7,11H,(H,12,13)(H,14,15)/b7-6-

Upstream product

• 108-31-6 maleic anhydride 
• 100-63-0 phenylhydrazine 

Downstream Products

• 101285-16-9 (3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-acetic acid-(N'-phenyl-hydrazide) 
• 54012-48-5 (4-oxo-3-propyl-2-thioxo-thiazolidin-5-yl)-acetic acid N'-phenyl-hydrazide 
• 54012-49-6 (3-cyclohexyl-4-oxo-2-thioxo-thiazolidin-5-yl)-acetic acid N'-phenyl-hydrazide 
• 54012-51-0 (3-anilino-4-oxo-2-thioxo-thiazolidin-5-yl)-acetic acid N'-phenyl-hydrazide 
• 54012-50-9 (3-benzyl-4-oxo-2-thioxo-thiazolidin-5-yl)-acetic acid N'-phenyl-hydrazide 
• 52726-96-2 1-(phenylamino)-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition

Dual inhibition of the enzymatic pathways of cyclooxygenases (COX-1/COX-2) and lipoxygenase (LOX) is a rational approach for developing more efficient and safe anti-inflammatory agents. Herein, dual inhibitors of COX and LOX for the management of inflammation are reported. The structural modifications of starting pyrrolidine-2,5-dione aldehyde derivatives resulted in two structurally diverse families (Family A & B). Synthesized derivatives from both Families displayed preferential COX-2 affinity in submicromolar to nanomolar ranges. Disubstitution pattern of the most active series of compounds having N-(benzyl(4-methoxyphenyl)amino moiety presents a new template that is mimic to the diaryl pattern of traditional COX-2 inhibitors. Compound 78 with IC50 value of 0.051 ± 0.001 μM emerged as the most active compound. Highly potent COX-2/5-LOX inhibitors have also demonstrated appreciable in-vivo anti-inflammatory activity through carrageenan induced paw edema test. Moreover, the involvement of histamine, bradykinin, prostaglandin, and leukotriene mediators to adjust the inflammatory response were also studied. Apart from COX inhibition, sulfonamide is considered an important template for carbonic anhydrase inhibition. Hence, we also evaluated six sulfonamide derivatives for off-target in-vitro bovine carbonic anhydrase-II inhibition. Biological results were finally rationalized by docking simulations. Typically, most active COX-2 inhibitors interact with the amino acid residues responsible for the COX-2 selectivity.

Triethylamine-catalyzed synthesis of oxazepine from maleamic acids

2-Thioxo-1,3-oxazepine-4,7-dione compounds were obtained via triethylamine-catalyzed condensation of maleamic acids with thiophosgene under anhydrous conditions. This method features relatively a simple methodology, use of inexpensive reagents, convenient operating conditions and high yields.

Homo and copolymerization of N-(phenylamino)maleimide: Synthesis and characterization

Free radical homopolymerization of N-(phenylamino)maleimide (N-PAMI) and copolymerization with methyl methacrylate (MMA) were performed at 65°C with AIBN as initiator in THF. The molecular weights of polymers were determined by gel permeation chromatograp