69360-08-3Relevant academic research and scientific papers
Synthesis method and application of isoxazole pyrimidine derivative
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Paragraph 0107-0109, (2022/01/20)
The invention relates to the technical field of organic molecule synthesis, and provides a synthesis method of an isoxazole pyrimidine derivative, in the synthesis method, firstly, 4-(A2)-2-(A1)-pyrimidine-5-carboxylic acid is provided as a raw material, and is sequentially subjected to an amide condensation reaction, a substitution reaction and a substitution cyclization reaction with different reactants, and through three simple reaction processes, the isoxazole pyrimidine derivative is finally obtained. In the reaction process, the reactants in each step are compounds conventionally available in the field, continuous reaction with 4-(A2)-2-(A1)-pyrimidine-5-carboxylic acid as a raw material is realized, the reaction time is shortened, the reaction efficiency is improved, large instruments and equipment do not need to be provided in the reaction process, and harsh reaction conditions are not need, and the method is convenient, simple, safe and reliable, is beneficial to large-scale preparation, and is suitable for industrial popularization and application.
