6937-35-5

Basic information

• Product Name: 2-(2-NITROPROP-1-ENYL)THIOPHENE
• Synonyms: 2-Nitro-1-(2-thienyl)propene ;2-Nitro-1-(thien-2-yl)prop-1-ene;Thiophene, 2-(2-nitro-1-propenyl)-;1-(2-Thienyl)-2-nitro-1-propene
• CAS NO: 6937-35-5
• Molecular Formula: C₇H₇NO₂S
• Molecular Weight: 169.20098
• Mol File: 6937-35-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 69°C
• Boiling Point: 273.5°C at 760 mmHg
• Flash Point: 119.2°C
• Appearance: /
• Density: 1.277g/cm³
• Vapor Pressure: 0.00957mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-(2-NITROPROP-1-ENYL)THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-NITROPROP-1-ENYL)THIOPHENE(6937-35-5)
• EPA Substance Registry System: 2-(2-NITROPROP-1-ENYL)THIOPHENE(6937-35-5)

Safety Data

• Hazardous Substances Data: 6937-35-5(Hazardous Substances Data)

Usage

General Description

2-(2-Nitroprop-1-enyl)thiophene is a complex organic chemical based on a thiophene backbone, a heterocyclic compound resembling benzene, but with a sulfur atom replacing one carbon atom. This specific compound is characterized by a nitropropenyl group attached to the thiophene ring. The nitro group indicates the presence of nitrogen and oxygen atoms, while the propenyl group is a subtype of the larger alkene functional group, characterized by a carbon-carbon double bond. This chemical may have various uses in scientific research and industry, for example in the synthesis of pharmaceuticals or as an intermediate in organic chemistry reactions. Properties and safety measures related to this chemical depend on its exact structure, which can be obtained from sources such as the Chemical Abstracts Service or similar databases.

InChI:InChI=1/C7H7NO2S/c1-6(8(9)10)5-7-3-2-4-11-7/h2-5H,1H3

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 79-24-3 Nitroethane 
• 98-03-3 thiophene-2-carbaldehyde 
• 27757-85-3 2-Aminomethylthiophene 

Downstream Products

• 30433-93-3 (+/-)-1-(methyl-2-thien-2-yl)ethylamine 
• 1442645-60-4 C₁₈H₁₇NO₂S 
• 1600521-11-6 1-(2,5-dimethyl-1-phenyl-4-(thiophen-2-yl)-1H-pyrrol-3-yl)ethanone 
• 1519057-78-3 2-methyl-1-phenyl-3-(thiophen-2-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 
• 1519057-38-5 2,6,6-trimethyl-1-phenyl-3-(thiophen-2-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 

Relevant articles and documents

Substrate promiscuity of ortho-naphthoquinone catalyst: Catalytic aerobic amine oxidation protocols to deaminative cross-coupling and n-nitrosation

ortho-Naphthoquinone-based organocatalysts have been identified as versatile aerobic oxidation catalysts. Primary amines were readily cross-coupled with primary nitroalkanes via deaminative pathway to give nitroalkene derivatives in good to excellent yields. Secondary and tertiary amines were inert to ortho-naphthoquinone catalysts; however, secondary nitroalkanes were readily converted by ortho-naphthoquinone catalysts to the corresponding nitrite species that in situ oxidized the amines to the corresponding N-nitroso compounds. Without using harsh oxidants in a stoichiometric amount, the present catalytic aerobic oxidation protocol utilizes the substrate promiscuity feature to provide a facile access to amine oxidation products under mild reaction conditions.

Synthesis of Benzo[4,5]imidazo[2,1-b]thiazole by Copper(II)-Catalyzed Thioamination of Nitroalkene with 1H-Benzo[d]imidazole-2-thiol

A Copper(II)-catalyzed thioamination of β-nitroalkene with 1H-benzo[d]imidazole-2-thiol has been developed for the synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives. A variety of N-fused benzoimidazothiazole derivatives are obtained in high yields through successive C?N and C?S bond formations. This protocol is also applicable to β-substituted β-nitroalkenes to afford 2,3-disubstituted benzoimidazothiazoles. (Figure presented.).

Iron-catalyzed tandem one-pot addition and cyclization of the blaise reaction intermediate and nitroolefins: Synthesis of substituted NH-pyrroles from nitriles

The iron-catalyzed addition and cyclization of the Blaise reaction intermediate and nitroolefins to synthesize highly functionalized NH-pyrroles in a tandem one-pot manner from nitriles has been developed. This reaction shows good functional group tolerance and affords a broad spectrum of substituted NH-pyrroles in good yields. Copyright