6937-35-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(2-Nitroprop-1-enyl)thiophene is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Organic Chemistry Research:
2-(2-NITROPROP-1-ENYL)THIOPHENE serves as a valuable research tool in organic chemistry, where it can be used to study reaction mechanisms, explore new synthetic pathways, and investigate the properties of related compounds.
Used in Chemical Intermediates:
2-(2-Nitroprop-1-enyl)thiophene is used as a chemical intermediate in the production of various specialty chemicals, where its unique structure can impart specific characteristics to the final products.
Safety Measures:
Properties and safety measures related to 2-(2-Nitroprop-1-enyl)thiophene depend on its exact structure, which can be obtained from sources such as the Chemical Abstracts Service or similar databases. It is essential to handle 2-(2-NITROPROP-1-ENYL)THIOPHENE with care, following appropriate safety protocols to minimize risks associated with its use.

InChI:InChI=1/C7H7NO2S/c1-6(8(9)10)5-7-3-2-4-11-7/h2-5H,1H3

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 79-24-3 Nitroethane 
• 98-03-3 thiophene-2-carbaldehyde 
• 27757-85-3 2-Aminomethylthiophene 

Downstream Products

• 1442645-60-4 C₁₈H₁₇NO₂S 
• 1600521-11-6 1-(2,5-dimethyl-1-phenyl-4-(thiophen-2-yl)-1H-pyrrol-3-yl)ethanone 
• 30433-93-3 (+/-)-1-(methyl-2-thien-2-yl)ethylamine 
• 1519057-78-3 2-methyl-1-phenyl-3-(thiophen-2-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 
• 1519057-38-5 2,6,6-trimethyl-1-phenyl-3-(thiophen-2-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 

Relevant academic research and scientific papers

Substrate promiscuity of ortho-naphthoquinone catalyst: Catalytic aerobic amine oxidation protocols to deaminative cross-coupling and n-nitrosation

ortho-Naphthoquinone-based organocatalysts have been identified as versatile aerobic oxidation catalysts. Primary amines were readily cross-coupled with primary nitroalkanes via deaminative pathway to give nitroalkene derivatives in good to excellent yields. Secondary and tertiary amines were inert to ortho-naphthoquinone catalysts; however, secondary nitroalkanes were readily converted by ortho-naphthoquinone catalysts to the corresponding nitrite species that in situ oxidized the amines to the corresponding N-nitroso compounds. Without using harsh oxidants in a stoichiometric amount, the present catalytic aerobic oxidation protocol utilizes the substrate promiscuity feature to provide a facile access to amine oxidation products under mild reaction conditions.

A diversity-oriented synthesis of polyheterocycles: Via the cyclocondensation of azomethine imine

Pd-Catalyzed sequential reactions to afford skeletally diverse molecules are described. The reaction involved azomethine imine formation and a cyclocondensation reaction as individual steps. The methodology provides excellent regio- and stereocontrol. Skeletal diversity was ensured by changing the electrophilic counterpart of azomethine imine. Due to its broader diversity and complexity, the DOS methodology is likely to benefit drug discovery and development in the future.

Synthesis of Benzo[4,5]imidazo[2,1-b]thiazole by Copper(II)-Catalyzed Thioamination of Nitroalkene with 1H-Benzo[d]imidazole-2-thiol

A Copper(II)-catalyzed thioamination of β-nitroalkene with 1H-benzo[d]imidazole-2-thiol has been developed for the synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives. A variety of N-fused benzoimidazothiazole derivatives are obtained in high yields through successive C?N and C?S bond formations. This protocol is also applicable to β-substituted β-nitroalkenes to afford 2,3-disubstituted benzoimidazothiazoles. (Figure presented.).

Synthesis of sulfonate derivatives of 4-heteryl-isoxazoles

Synthesis procedure of 3,5-dimethyl-4-heteryl-isoxazoles by reaction between heterocyclic aldehydes and nitroethane in the presence of base was developed. Sulfochlorination of the resulting compounds was studied.

Iron-catalyzed tandem one-pot addition and cyclization of the blaise reaction intermediate and nitroolefins: Synthesis of substituted NH-pyrroles from nitriles

The iron-catalyzed addition and cyclization of the Blaise reaction intermediate and nitroolefins to synthesize highly functionalized NH-pyrroles in a tandem one-pot manner from nitriles has been developed. This reaction shows good functional group tolerance and affords a broad spectrum of substituted NH-pyrroles in good yields. Copyright

SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS

The object of the present invention is novel substituted pyrrolidine amides of the general formula (I) in which D, L. E, G, J, M, L1, L2, R4, and R5 are defined as in the specification, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, particularly physiologically tolerated salts with inorganic or organic acids or bases having valuable properties.

CARBOXYLIC ACID AMIDES AS FACTOR XA INHIBITORS

The present invention relates to new substituted carboxylic acid amides of general formula (I), wherein D, B, R3, R4 and R5 are defined as in the specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.