6937-38-8

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-1-(1H-indol-3-yl)-3-phenylprop-2-en-1-one is used as a key structural component in the development of pharmaceutical compounds for various diseases. Its potential biological and pharmacological activities, such as antimicrobial, anti-inflammatory, and anticancer properties, make it a promising candidate for drug discovery and development.
Used in Biological Research:
(2E)-1-(1H-indol-3-yl)-3-phenylprop-2-en-1-one is used as a research tool in biological studies to investigate the mechanisms of action and potential applications of compounds containing an indole moiety and phenylpropenone group. (2E)-1-(1H-indol-3-yl)-3-phenylprop-2-en-1-one can provide valuable insights into the development of new therapeutic agents and understanding the underlying biological processes.
Used in Medicine:
(2E)-1-(1H-indol-3-yl)-3-phenylprop-2-en-1-one has the potential for various applications in the field of medicine, particularly in the treatment of diseases where its pharmacological activities can be utilized. Its potential as a therapeutic agent for various diseases, including antimicrobial, anti-inflammatory, and anticancer properties, makes it a valuable compound for medical research and treatment development.

Upstream product

• 120-72-9 indole 
• 102-92-1 cinnamoyl chloride 
• 703-80-0 3-acetylindole 
• 100-52-7 benzaldehyde 

Downstream Products

• 716305-05-4 1-[3-(1H-indol-3-yl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone 
• 639085-63-5 4-(1H-indol-3-yl)-2-phenyl-2,3-dihydro-benzo[b][1,4]thiazepine 
• 639085-67-9 8-(1H-indol-3-yl)-6-phenyl-6,7-dihydro-5-oxa-9-aza-benzocycloheptene 

Relevant academic research and scientific papers

Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies

The synthesis of novel indolopyrazoline derivatives (P1-P4 and Q1-Q4) has been characterized and evaluated as potential anti-Alzheimer agents through in vitro Acetylcholinesterase (AChE) inhibition and radical scavenging activity (antioxidant) studies. Sp

Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1

Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast. Here, we demonstrate a one-pot three-component reaction via a [3 + 2] cycloaddition/ring contraction sequence of a dipolarophile (activated alkene) with in situ-generated azomethine ylide (1,3-dipoles) without the use of any catalyst. The reaction provides efficient access to synthetically useful and biologically important spirooxindoles in high yield (69-94%) with high diastereoselectivity. The synthesized compounds were subjected to cytotoxicity evaluation using colorectal cancer (HCT-116), hepatocellular carcinoma (HepG2), and prostate cancer (PC-3) cells. Compounds 4i, 4j, and 4k showed potent cytotoxic activity and high selectivity against HCT-116 cells when compared to cisplatin. Meanwhile compound 4d retained high cytotoxic activity and selectivity against HepG2 and PC-3 cells in comparison to cisplatin. The mechanism of compound 4d was further studied using phosphodiesterase 1 enzyme and showed 74.2% inhibitory activity. A possible binding mode for compound 4d to PDE-1 was investigated by molecular modeling using OpenEye software. Pose predictions for the active compounds were demonstrated by ROCS alignments. Compound 4d has a special geometry and differs from other active compounds.

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

ZrCl4-mediated regio- and chemoselective friedel-crafts acylation of indole

An efficient method for regio- and chemoselective Friedel-Crafts acylation of indole using acyl chlorides in the presence of ZrCl4 has been discovered. It minimizes/eliminates common competing reactions that occur due to high and multiatom-nucleophilic character of indole. In this method, a wide range of aroyl, heteroaroyl alkenoyl, and alkanoyl chlorides undergo smooth acylation with various indoles without NH protection and afford 3-acylindoles in good to high yields.

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

Synthesis and antiinflammatory activity of heterocyclic indole derivatives

Chalcones of indole 1-5 and their corresponding products; pyrazolines 6-10 and azo compounds 11-15 were synthesised and evaluated for their antiinflammatory activity against carrageenan induced oedema in albino rats at a dose of 50 mg kg-1 oral

Synthesis of some new benzothia/oxazepinyl indoles as an antipsychotic agents

Some new 3-(2′-substitutedaryl-2′,3′-dihydro-1′, 5′-benzothia/oxazepin-4′-yl)indoles 3a-h, 3-(2′-substitutedaryl-3′-substitutedarylaminomethylene-2′, 3′-dihydro-1′,5′-benzothia/oxazepin-4′-yl)indoles 4a-p and 3-(2′-substitutedaryl-3′-substitutedarylazo-2′