693803-44-0

Basic information

• Product Name: Carbamic acid, methyl(4-methylphenyl)-, 1,1-dimethylethyl ester
• CAS NO: 693803-44-0
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol File: 693803-44-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Carbamic acid, methyl(4-methylphenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, methyl(4-methylphenyl)-, 1,1-dimethylethyl ester(693803-44-0)
• EPA Substance Registry System: Carbamic acid, methyl(4-methylphenyl)-, 1,1-dimethylethyl ester(693803-44-0)

Safety Data

• Hazardous Substances Data: 693803-44-0(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 623-08-5 N-methyl-p-toluidine 
• 106-49-0 p-toluidine 
• 14618-59-8 N-(tert-butoxycarbonyl)-4-methylaniline 
• 74-88-4 methyl iodide 

Downstream Products

• 1220120-62-6 dimethylphenylsilyl N-p-tolyl-N-methylcarbamate 
• 115-11-7 isobutene 
• 612-03-3 4-(N-methylacetamido)toluene 
• 623-08-5 N-methyl-p-toluidine 
• 835872-99-6 N-(2-iodo-4-methylphenyl)methylamine 
• 168830-88-4 [4-(4-benzhydrylcarbamoyloxy-piperidin-1-ylmethyl)-phenyl]-methyl-carbamic acid tert-butyl ester 
• 168830-70-4 benzhydryl-carbamic acid 1-(4-methylamino-benzyl)-piperidin-4-yl ester 
• 168830-93-1 tert-butyl (4-(bromomethyl)phenyl)(methyl)carbamate 

Relevant articles and documents

Hydrosilane-Promoted Facile Deprotection of tert-Butyl Groups in Esters, Ethers, Carbonates, and Carbamates

Combination of PdCl2 with 1,1,3,3-tetramethyldisiloxane in the presence of activated carbon was found to be an effective catalyst system for the cleavage reaction of C?O bond of O?t-Bu moieties. The present catalytic reaction offers a practical method for the deprotection of tert-butyl esters, tert-butyl ethers, O-Boc, and N-Boc derivatives under mild conditions. The addition of activated carbon in the reaction mixture was proved to be crucial for not only sustaining the catalytic activity but also trapping the palladium species after the reaction. (Figure presented.).

Palladium-catalyzed oxidative carbonylation of aromatic C-H bonds of N -alkylanilines with CO and alcohols for the synthesis of o -aminobenzoates

A Pd(II)-catalyzed C-H monocarbonylation of N-alkylanilines for the synthesis of o-aminobenzoates has been developed. Various aliphatic alcohols and phenol were tolerated in the reaction to afford the corresponding o-aminobenzoates in good yields under mild balloon pressure of CO.

Silver-catalyzed incorporation of carbon dioxide into o-alkynylaniline derivatives

Benzoxazine-2-one derivatives are important heterocycle structures because of their various pharmaceutical activities, though their synthetic methods had been limited. In some cases, toxic reagents, such as phosgene or carbon monoxide, are required. It was found that a silver catalyst successfully promoted the incorporation of CO2 into o-alkynylanilines to afford the corresponding benzoxazine-2-ones bearing Z exo-olefin via 6-exo-dig cyclization at the activated C-C triple bond.