693826-78-7Relevant articles and documents
Fluorinated (hetero)cycles via ring-closing metathesis of fluoride- and trifluoromethyl-functionalized olefins
De Matteis, Valeria,Van Delft, Floris L.,De Gelder, René,Tiebes, J?rg,Rutjes, Floris P.J.T.
, p. 959 - 963 (2004)
Ring-closing metathesis (RCM) has been shown to be a viable tool to incorporate fluoride and trifluoromethyl substituents in (hetero)cyclic ring systems. 2-Fluoroacrylamides were cyclized to the corresponding lactams, and trifluoromethyl-substituted olefi
RCM-mediated synthesis of trifluoromethyl-containing nitrogen heterocycles
De Matteis, Valeria,Van Delft, Floris L.,Jakobi, Harald,Lindell, Stephen,Tiebes, Joerg,Rutjes, Floris P. J. T.
, p. 7527 - 7532 (2007/10/03)
(Chemical Equation Presented) A ring-closing metathesis mediated pathway to trifluoromethyl-containing piperidines is detailed. This involves the development of a synthetic route to a new (trifluoromethyl)allylating reagent via a Diels-Alder/retro-Diels-Alder strategy, its application in the synthesis of a series of trifluormethyl-substituted diolefin recursors for ring-closing metathesis, and eventually the successful cyclization of these precursor molecules into the corresponding functionalized piperidines.
