693827-77-9Relevant academic research and scientific papers
AMINO PYRAZOLONE DERIVATIVE HAVING CONDENSED RING STRUCTURE
-
, (2016/10/08)
PROBLEM TO BE SOLVED: To provide a compound that has excellent inhibitory action on ATPase activity of TIP48/TIP49 complex and is therefore useful for the treatment of tumor, or a pharmacologically acceptable salt thereof. SOLUTION: The present invention provides a compound having a structure represented by general formula (I), its pharmacologically acceptable salt, or a pharmaceutical composition comprising the compound (where R3, R4, R5, R6, R7, W, X, Y, and Z are as defined in the specifications). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
Synthesis of N-substituted cyclic triglycines and their response to metal ions
Hioki, Hideaki,Kinami, Hiroyuki,Yoshida, Atsushi,Kojima, Aoi,Kodama, Mitsuaki,Takaoka, Shigeru,Ueda, Keisuke,Katsu, Takashi
, p. 1091 - 1094 (2007/10/03)
N,N′,N″-Trisubstituted-cyclo-triglycines were synthesized. The major conformation of these compounds has C3 symmetry, and the carbonyl groups and substituents on the nitrogen are inclined in the same direction. Their response to various metal ions was estimated by constructing ion-selective electrodes. Two of them responded selectively to Ca2+ over other cations, demonstrating that N,N′,N″-trisubstituted-cyclo- triglycines provide a new scaffold to act as host molecules.
