69384-66-3

Basic information

• Product Name: 3,3'-Dithiobis(benzoic acid chloride)
• Synonyms: 3,3'-Dithiobis(benzoic acid chloride)
• CAS NO: 69384-66-3
• Molecular Formula: C₁₄H₈Cl₂O₂S₂
• Molecular Weight: 0
• Mol File: 69384-66-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,3'-Dithiobis(benzoic acid chloride)(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-Dithiobis(benzoic acid chloride)(69384-66-3)
• EPA Substance Registry System: 3,3'-Dithiobis(benzoic acid chloride)(69384-66-3)

Safety Data

• Hazardous Substances Data: 69384-66-3(Hazardous Substances Data)

Upstream product

• 1227-49-2 3,3'-dithiobis-benzoic acid 

Downstream Products

• 1069086-74-3 C₂₂H₂₄N₂O₄S₂ 
• 107920-19-4 3,3'-dithiodibenzamide 
• 69383-99-9 bis(3-(dimethylaminomethyl)phenyl) disulfide 
• 115484-14-5 3,3'-disulfanediyl-di-benzoic acid-dianilide 

Relevant articles and documents

Preparation method of dithiobenzamide compound

The invention provides a preparation method of a dithiobenzamide compound, and relates to the technical field of organic synthesis. The method disclosed by the invention has the advantages that applicable substrates are richer, and the method can be used for synthesizing various dithiodibenzoyl compounds; reaction conditions are mild, the synthesis reaction process is simple to operate, and practicability is achieved; the post-treatment operation is simple and convenient, and the product yield and purity are high; and the reaction process is green and environment-friendly, and the preparationmethod meets the requirements of large-scale industrial production.

A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2'-dithiobisbenzamides

As part of the National Cancer Institute's Drug Screening Program, a new class of antiretrovirals active against the human immunodeficiency virus HIV-1 has been identified, and the HIV-1 nucleocapsid protein NCp7 was proposed as the target of antiviral action. The 2,2'-dithiobis-[4'-(sulfamoyl)benzanilide] (3x) and the 2,2'-dithiobis(5-acetylamino)benzamide (10) represented the prototypic lead structures. A wide variety of 2,2'-dithiobisbenzamides were prepared and tested for anti-HIV-1 activity, cytotoxicity, and their ability to extrude zinc from the zinc fingers for NCp7. The structure-activity relationships demonstrated that the ability to extrude zinc from NCp7 resided in the 2,2'-dithiobisbenzamide core structure. The 3,3' and the 4,4' isomers were inactive. While many analogs based upon the core structure retained the zinc extrusion activity, the best overall anti-HIV-1 activity was only found in a narrow set of derivatives possessing carboxylic acid, carboxamide, or phenylsulfonamide functional groups. These functional groups were more important for reducing cytotoxicity than improving antiviral potency or activity vs NCp7. All of the compounds with antiviral activity also extruded zinc from NCp7. From this study several classes of low μM anti-HIV agents with simple chemical structures were identified as possible chemotherapeutic agents for the treatment of AIDS.