352303-65-2

Basic information

• Product Name: 1-(2,6-DIFLUORO-BENZYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE
• Synonyms: 1-(2,6-DIFLUORO-BENZYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE;1-[(2,6-Difluorophenyl)methyl]-6-methyl-pyrimidine-2,4-dione
• CAS NO: 352303-65-2
• Molecular Formula: C₁₂H₁₀F₂N₂O₂
• Molecular Weight: 252.22
• Mol File: 352303-65-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.367g/cm³
• Refractive Index: 1.553
• CAS DataBase Reference: 1-(2,6-DIFLUORO-BENZYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-DIFLUORO-BENZYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE(352303-65-2)
• EPA Substance Registry System: 1-(2,6-DIFLUORO-BENZYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE(352303-65-2)

Safety Data

• Hazardous Substances Data: 352303-65-2(Hazardous Substances Data)

Usage

General Description

1-(2,6-DIFLUORO-BENZYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE is a chemical compound with the molecular formula C13H9F2N2O2. It is a pyrimidinedione derivative that contains a benzyl group with two fluorine atoms and a methyl substituent. 1-(2,6-DIFLUORO-BENZYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE has potential applications in medicinal chemistry, particularly in the development of pharmaceutical drugs due to its structural features and potential biological activities. Its precise properties and uses may vary depending on the specific field of study and application.

InChI:InChI=1/C12H10F2N2O2/c1-7-5-11(17)15-12(18)16(7)6-8-9(13)3-2-4-10(8)14/h2-5H,6H2,1H3,(H,15,17,18)

Upstream product

• 17751-24-5 N-(2,6-difluorobenzyl) urea 
• 69385-30-4 2,6-difluorobenzylamine 
• 674-82-8 4-methyleneoxetan-2-one 
• 618914-13-9 1-(2,6-difluorobenzyl)-3-(3-oxobutyryl)urea 

Downstream Products

• 352292-05-8 1-(2,6-difluoro-benzyl)-3-[2-(3-isobutoxy-propylamino)-propyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione 
• 352291-93-1 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[2-(2-pyridin-2-yl-ethylamino)-propyl]-1H-pyrimidine-2,4-dione 
• 352293-98-2 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione 
• 352291-90-8 3-(2-benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione 
• 352292-25-2 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-pyrrolidin-2-ylmethyl-1H-pyrimidine-2,4-dione 
• 618914-15-1 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-(2-oxo-propyl)-1H-pyrimidine-2,4-dione 
• 618914-14-0 5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-3-(2-methyl-allyl)-1H-pyrimidine-2,4-dione 

Relevant articles and documents

5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers

Optimization of a series of uracils bearing a 2-fluoro- or 2-chloro-3-methoxyphenyl group at the 5-position resulted in compounds such as 3d and 3f with subnanomolar binding affinity at the human GnRH receptor. While the 2-fluoro-3-methoxyphenyl compound 3a was characterized as a mixture of interchangeable atropisomers, the diastereoisomers of 2-chloro-3-methoxyphenyl analogs were separated. It was found that the aR-atropisomer was much more potent than the aS-isomer based on the X-ray crystal structure of 3h-II.

Synthesis and Structure-Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists

Based on the SAR from bicyclic gonadotropin-releasing hormone (GnRH) antagonists such as 6-aminomethyl-7-aryl-pyrrolo [1,2-a] pyrimid-4-ones (5) and 2-aryl-3-aminomethyl-imidazolo-[1,2-a]pyrimid-5-ones (6a,b), a series of novel uracil compounds (8) were d

Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists

The novel synthesis and SAR studies of 6-methyluracils as human GnRH receptor antagonists are discussed. Introduction of a small methyl substituent at the β-position from N3 of the uracil improved the GnRH binding potency by 5- to 10-fold. The best compou