69395-50-2Relevant academic research and scientific papers
Synthesis of antimicrobial agents. IV. Synthesis of 1-hydroxypiperazine dihydrochloride and its applications to pyridone carboxylic acid antibacterial agents
Uno,Okuno,Taguchi,Iuchi,Kawahata,Sotomura,Tsukamoto
, p. 393 - 396 (1989)
1-Hydroxypiperazine dihydrochloride 7 was prepared and it was applied to the syntheses of new pyridone carboxylic acid antibacterial agents (PCA-antibacterial agents). 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxypiperazin-1-yl(-4- oxoquinoline-3-carboxylic acid 13 showed the most potent antibacterial activity.
