Journal of Heterocyclic Chemistry p. 393 - 396 (1989)
Update date:2022-08-04
Topics:
Uno
Okuno
Taguchi
Iuchi
Kawahata
Sotomura
Tsukamoto
1-Hydroxypiperazine dihydrochloride 7 was prepared and it was applied to the syntheses of new pyridone carboxylic acid antibacterial agents (PCA-antibacterial agents). 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxypiperazin-1-yl(-4- oxoquinoline-3-carboxylic acid 13 showed the most potent antibacterial activity.
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