69399-59-3Relevant academic research and scientific papers
A reverse method for diversity introduction of benzimidazole to synthesize H+/K+-ATP enzyme inhibitors
Yan, Yu,Liu, Zijie,Zhang, Jianjun,Xu, Ruiming,Hu, Xiao,Liu, Gang
supporting information; experimental part, p. 4189 - 4192 (2011/08/10)
A series of 2-[(2-pyridylmethyl)sulfinyl]benzimidazole derivatives were synthesized via a solution phase synthetic route using a reversal method of diversity introduction. Using this synthetic strategy, we obtained two key intermediates (4-A and 4-B) simultaneously, which allows us to introduce diversity points onto the benzimidazole part of the final product under reliable reaction conditions to identify potent H+/K+-ATP enzyme inhibitors. Compound 14l (IC50 = 1.6 × 10-5 M) was comparable with H+/K+-ATP enzyme inhibitor in vitro.
Process for the manufacture of benzimidazolones-(2)
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, (2008/06/13)
Process for the manufacture of benzimidazolones-(2) wherein an o-phenylenediamine is reacted with optionally alkylated urea in the ratio of 1 to 1.3 moles per mole o-phenylenediamine in an organic solvent which has a solubility in water of not more than 5 g/l and has a boiling point above 100° C, at a temperature between 100° and 200° C.
