69407-32-5

Basic information

• Product Name: N-BENZYL-BISPIDINE
• Synonyms: N-BENZYL-BISPIDINE;3-Benzyl-3,7-diaza-bicyclo[3.3.1]nonane
• CAS NO: 69407-32-5
• Molecular Formula: C₁₄H₂₀N₂
• Molecular Weight: 216.32
• Mol File: 69407-32-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-BENZYL-BISPIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYL-BISPIDINE(69407-32-5)
• EPA Substance Registry System: N-BENZYL-BISPIDINE(69407-32-5)

Safety Data

• Hazardous Substances Data: 69407-32-5(Hazardous Substances Data)

Upstream product

• 227940-71-8 tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3. 1]-nonane-3-carboxylate 
• 227940-70-7 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester 
• 59009-71-1 N,N'-dibenzyl-3,7-diazabicyclo[3.3.1]nonane 

Downstream Products

• 313476-84-5 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-ethanol 
• 313476-55-0 7-benzyl-N-ethyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxamide 
• 227940-71-8 tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3. 1]-nonane-3-carboxylate 
• 313476-50-5 N-{2-(7-Benzyl-3,7-diazabicyclo[3.3.1]non-3-yl)-1-[(4-cyanophenoxy)-methyl]ethyl}methanesulfonamide 
• 313476-72-1 3-benzyl-7-[3-(2-propyl-1,3-dioxolan-2-yl)propyl]-3,7-diazabicyclo[3.3.1]nonane 
• 1184703-36-3 1-(7-benzyl-3,7-diaza-bicyclo[3.3.1]non-3-yl)-ethanone 
• 58324-95-1 3-benzyl-7-methyl-3,7-diazabicyclo[3.3.1]nonane 

Relevant articles and documents

Synthesis and evaluation of dual antiplatelet activity of bispidine derivatives of N-substituted pyroglutamic acids

N-aralkylpyroglutamides of substituted bispidine were prepared and evaluated for their ability to inhibit collagen induced platelet aggregation, both in vivo and in vitro. Some compounds showed high anti-platelet efficacy (in vitro) of which six inhibited

3,7-DIAZABICYCLO[3.3.1 ]NONANE CARBOXAMIDES AS ANTITHROMBOTIC AGENTS

The present invention relates to the 3,7-diazabicyclo[3.3.1]nonane carboxamides and process for preparation thereof. The present invention further relates to the compounds of general formula (1) possessing anti-thrombotic (anti-platelet) activities. The invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors both in vitro and in vivo. Further, invention also relates these class of compounds exhibiting anti-platelet efficacy through dual mechanism inhibited both collagen as well as U46619 (thromboxane receptor agonist) induced platelet aggregation. General formula (1) Wherein, R' is; wherein R is selected from alkyl, acyl, tosyl, tert-butyloxycarbonyl, araalkyl or substituted araalkyl groups; R'' is selected preferably from halogen, cyano, lower alkyl, aryl, substituted aryl, and tosyl groups; R1 is selected from hydrogen and lower alkyl groups; R2 is selected from lower alkyl and aryl groups; R3 is selected from tert-butyloxycarbonyl and bezyloxycarbonyl groups; n = 0,1.

Bispidine compounds useful in the treatment of cardiac arrythmias

There is provided compounds of formula I, 1 wherein R1, R2, R3, R4, R5, R6, R7, R41, R42, R43 R44, R45, R46, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.