6942-69-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(biphenyl-4-yl)-2-oxoethyl 3-methylbenzoate is used as a synthetic intermediate for the development of pharmaceutical compounds due to its unique structural features that may contribute to the creation of novel drug molecules with specific therapeutic properties.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-(biphenyl-4-yl)-2-oxoethyl 3-methylbenzoate serves as a starting material for the preparation of other organic molecules, facilitating the exploration of new chemical reactions and the synthesis of new compounds with potential applications in various industries.
Used in Chemical Industry:
2-(biphenyl-4-yl)-2-oxoethyl 3-methylbenzoate is utilized as a specialty chemical in the chemical industry, where its distinct structure may offer advantages in the formulation of new products or the improvement of existing ones, pending further investigation into its reactivity and compatibility with other substances.

Upstream product

• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 92-91-1 biphenyl-4-acetaldehyde 
• 92-52-4 biphenyl 
• 99-04-7 m-Toluic acid 

Relevant academic research and scientific papers

Novel biphenyl ester derivatives as tyrosinase inhibitors: Synthesis, crystallographic, spectral analysis and molecular docking studies

Biphenyl-based compounds are clinically important for the treatments of hypertension and inflammatory, while many more are under development for pharmaceutical uses. In the present study, a series of 2-([1,1'-biphenyl]-4-yl)-2-oxoethyl benzoates, 2(a-q), and 2-([1,1'- biphenyl]-4-yl)-2-oxoethyl pyridinecarboxylate, 2(r-s) were synthesized by reacting 1-([1,1'- biphenyl]-4-yl)-2-bromoethan-1-one with various carboxylic acids using potassium carbonate in dimethylformamide at ambient temperature. Single-crystal X-ray diffraction studies revealed a more closely packed crystal structure can be produced by introduction of biphenyl moiety. Five of the compounds among the reported series exhibited significant antityrosinase activities, in which 2p, 2r and 2s displayed good inhibitions which are comparable to standard inhibitor kojic acid at concentrations of 100 and 250 μg/mL. The inhibitory effects of these active compounds were further confirmed by computational molecular docking studies and the results revealed the primary binding site is active-site entrance instead of inner copper binding site which acted as the secondary binding site.