69457-02-9

Upstream product

• 10475-63-5 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester 

Downstream Products

• 1268701-83-2 triethyl 6-methyl-3-phenyl-1,2,3,4-tetrahydro-1,2,3,4-tetrazine-1,2,5-tricarboxylate 
• 1268701-70-7 ethyl 6-[ethoxycarbonyl-(phenylhydrazono)-methyl]-4-methyl-1-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate 
• 1268701-67-2 1,2-bis(2-ethoxycarbonylindol-3-yl)ethene 
• 80447-71-8 phenylhydrazone of ethyl ester of glyoxalic acid 
• 1268701-78-5 ethyl 4-methyl-5,7-dioxo-1,6-diphenyl-4,4a,5,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridazine-3-carboxylate 

Relevant academic research and scientific papers

Pyrolysis of 3-hydroxy-2-arylhydrazonoalkanoic acid derivatives

1,2-Diaza-1,3-butadienes have been obtained from readily available 3-hydroxy-2-arylhydrazonopropanoates under various reaction conditions including pyrolysis, dehydration under Mitsunobu conditions or with acetic anhydride or acetic acid. According to their method of synthesis these 1,2-diaza-1,3- butadienes underwent subsequent reactions to give interesting products, and in the presence of proper dienophiles gave the corresponding cycloaddition products. Also, a new approach to pyrazole-3-carboxylic acid derivatives was discovered during an attempt to dehydrate 3-hydroxy-2-arylhydrazonobutanoic esters.